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成人Still病患者外周血白细胞介素-17水平及其临床意义

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摘要 成人Still病（AOSD）是一种罕见的炎性自身免疫病，临床上以高热、一过性皮疹、关节炎（痛）为主要表现，伴有外周血白细胞计数升高、肝脾及淋巴结肿大等系统受累的临床综合征[1]。有研究提示，活动期的AOSD患者血清中多种细胞因子水平升高是AOSD主要临床表现的原因[2]。
作者 赵萌萌 侯林欣 肖卫国
机构地区 中国医科大学附属第一医院风湿免疫科 中国医科大学附属盛京医院风湿免疫科
出处 《中华内科杂志》 CAS CSCD 北大核心 2013年第6期511-512,共2页 Chinese Journal of Internal Medicine
基金 辽宁省医学高峰工程建设项目（2010006）
关键词 外周血白细胞计数 STILL病 细胞因子水平 白细胞介素-17 临床意义 患者 成人 AOSD
分类号 R593 [医药卫生—内科学]
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参考文献11

  • 1Kontzias A, Efthimiou P. Aduh-onset Still' s disease: pathogenesis, clinical manifestations and therapeutic advances. Drugs ,2008,68:319-337.
  • 2Arlet JB, Le Thi Huong DB, Pouchot J, et al. Current concepts on the physiopathology of adult-onset Still's disease. Rev Med Interne ,2005,26:549-556.
  • 3Annunziato F, Cosnai L, Liotta F, et al. Type 17 T helper cells- origins, features and possible roles in rheumatic disease. Nat Rev Rheumatol, 2009,5 : 325 -331.
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  • 7唐碧霞,张烜,唐福林.IL-17与自身免疫性疾病关系的研究进展[J].基础医学与临床,2008,28(1):94-97. 被引量：32
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二级参考文献21

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  • 7Harrington LE, Hatton RD, Mangan PR, et al. Interleukin 17-producing CD4^+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages [ J ]. Nat Immunol, 2005,6 : 1123 - 1132.
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  • 9Ivanov II, McKenzie BS, Zhou Liang, et al. The orphan nuclear receptor rorgammat directs the differentiation program of proinflammatory IL-17 + T helper cells[ J]. Cell, 2006,126(6) :1121 - 1133.
  • 10Weaver CT, Harrington LE, Mangan PR, et al. Th17: An effector CD4 T cell lineage with regulatory T cell ties [ J ]. Immunity, 2006,24:677 - 688.

共引文献31

中华内科杂志
2013年 第6期

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