期刊文献+

阿司匹林对老年人拔牙术后出血影响的临床观察 被引量:15

Clinical evaluation of influence of aspirin on post-operative bleeding after tooth extraction in the elderly
原文传递
导出
摘要 目的探讨老年人拔牙术前不停服阿司匹林的可行性。方法600例均为拔除非阻生单颗牙的60岁以上患者,300例使用利多卡因局麻,其中200例未服用阿司匹林者为空白对照组I,100例长期服用阿司匹林且术前不停药者为观察组I;300例使用复方阿替卡因局麻,其中200例未服用阿司匹林者为空白对照组Ⅱ,100例长期服用阿司匹林且拔牙术前不停药者为观察组Ⅱ。观察研究对象拔牙创不同时间段出血情况,分析口服阿司匹林对拔牙术后不同时间段出血的影响。结果观察组I与空白对照组I拔牙术后5、10、30min、24h出血比较,差异均无统计学意义(P〉0.05);观察组Ⅱ拔牙术后5min出血发生率(19.0%)显著高于空白对照组Ⅱ(6.5%),但两组拔牙术后10、30min、24h出血比较,差异均无统计学意义(P〉0.05)。结论口服阿司匹林对老年人非阻生单颗牙拔除术后出血无影响,拔牙术前可不停服阿司匹林。 Objective To investigate the feasibility of continuation of aspirin before tooth extraction in the elderly. Methods The patients enrolled in this study were the elderly requiring a single non-impacted tooth extraction. 300 elderly outpatients used lidocaine local infiltration anesthesia, 200 patients without using aspirin before tooth extraction served as control group I , 100 patients with prolong use of aspirin before tooth extraction as observation group I . 300 elderly outpatients used compound articaine local infiltration anesthesia, 200 patients without using aspirin before tooth extraction served as control group Ⅱ , 100 patients with prolong use of aspirin before tooth extraction as observation group Ⅱ. Bleedings at 5, 10, 30 min, 24 h after tooth extraction were observed and the relationship between postoperative bleeding and intake of aspirin was analyzed. Results There was no significant difference at 5, 10,30 min,24 h in postoperative bleeding after extraction between control group I and observation group. The incidence of bleeding of observation group Ⅱ after tooth extraction at 5 min was higher than that of control group lI and there was no significant difference at 10,30 min, 24 h between the two groups. Conclusions Continuation of aspirin have no influence on postoperative bleeding. Therefore we suggest that there was no indication to discontinue aspirin for the elderly before a single non-impacted tooth extraction.
出处 《中华口腔医学杂志》 CAS CSCD 北大核心 2013年第5期262-265,共4页 Chinese Journal of Stomatology
基金 基金项目:中央保健委员会办公室资助课题(B20098004)
关键词 阿司匹林 老年人 拔牙 出血时间 Aspirin Aged Tooth extraction Bleeding time
  • 相关文献

参考文献6

二级参考文献12

  • 1潘瑞彭.血液学及血液学检验[M].北京:人民卫生出版社,1996.206-208.
  • 2U. S. Preventive Services Task Force. Aspirin for the prevention of cardiovascular disease:U. S. Preventive Services Task Force Rec- ommendation Statement [ J ]. Ann Intern Med, 2009, 150 ( 6 ) : 396 - 404.
  • 3Hansson L, Zanchetti A, Carruthers S, et al. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hy- pertension:principal results of the Hypertension Optimal Treatment (HOT) randomised trial[J]. Lancet, 1998,351 (9118) :1755 - 1762.
  • 4Jardine M J, Ninomiya T, Perkovic V, et al. Aspirin is bene? cial in hypertensive patients with chronic kidney disease. A post-hoc sub- group analysis of a randomized controlled trial [ J ]. J Am Coll Car- diol,2010,56(12) :956 -965.
  • 5Berger AK, Duval S, Krumholz HM. Aspirin, beta-blocker, and an- giotensin-eonverting enzyme inhibitor therapy in patients with end- stage renal disease and an acute myocardial infarction [ J ]. J Am Coll Cardiol, 2003,42 ( 2 ) :201 - 208.
  • 6Ong G, Davis TM, Davis WA. Aspirin is associated with reduced cardiovascular and all-cause mortality in type 2 diabetes in a pri- mary prevention setting [ J ]. Diabetes Care, 2010,33 ( 2 ) : 317 - 321.
  • 7Belch J, MacCuish A, Campbell I, et al. The prevention of progres- sion of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial disease [ J]. BMJ,2008,337 :a1840.
  • 8Ogawa H, Nakayama M, Morimoto T,et al. Low-dose aspirin for primary prevention of atherosclerotic events in patients with type 2 diabetes : a randomized controlled trial [ J ]. JAMA, 2008, 300 (18) :2134 -2141.
  • 9Wood RL, Tonkin AM, Nelson MR, et al. Should aspirin be used for the primary prevention of cardiovascular disease in people with diabetes? [J]. Med J Aust,2009,190( 11 ) :614 -615.
  • 10Pignone M, Alberts M J, ColweU JA, et al. Aspirin for primary pre- vention of cardiovascular events in people with diabetes :a position statement of the American Diabetes Association, a scientific state- ment of the American Heart Association, and an expert consensus document of the American College of Cardiology Foundation [ J ]. Circulation,2010,121 ( 24 ) : 2694 - 2701.

共引文献63

同被引文献123

引证文献15

二级引证文献43

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部