摘要
目的观察帕罗西汀联合行为干预治疗脑卒中后抑郁的临床疗效。方法将98例脑卒中后抑郁患者随机分为实验组与对照组各49例。对照组予以常规帕罗西汀药物治疗,实验组在此基础上进行行为干预治疗,观察两组抑郁及神经功能恢复情况。结果通过HAMD抑郁评分量表评定,治疗后实验组与对照组的治疗有效率分别为91.8%和79.6%,结果比较差异有统计学意义(P<0.05)。通过BI评分与SS-QOL评分,治疗后实验组与对照组相比BI评分明显上升,SS-QOL评分明显下降,差异有统计学意义(P<0.05)。且治疗过程中,实验组不良反应明显较少。结论帕罗西汀联合行为干预治疗脑卒中后抑郁能显著改善抑郁、提高神经功能,且不良反应较少,是治疗脑卒中后抑郁的好方法,值得临床推广。
Objective To explore the clinical efficacy of paroxetine combined with behavioral intervention in the treatment of post-stroke depression. Methods Ninety-eight patients of post-stroke depression treated in our hospital were randomly divided into the experimental group and the control group, with 49 patients in each group. The control group was given conventional medication treatment by paroxetine, while the experimental group was given behavioral intervention on the basis of the control group. The depression and nerve function recovery were observed in the two groups. Results According to HAMD Depression Rating Scale, the effective rate was 91.2% in the experimental group and 79.6% in the control group, with statistically significant difference between the two groups （P〈0.05）. In the experimental group, the BI scores increased significantly and SS-QOL score decreased signifi- cantly, compared with the control group （P〈0.05）. The adverse reactions during the treatment in the experimental group were significantly less. Conclusion Paroxetine combined with behavioral intervention in the treatment of post-stroke depression can significantly improve depression and nerve function, with less adverse reactions. It is a good treatment for post-stroke depression and is worthy of promotion.
出处
《海南医学》
CAS
2013年第11期1577-1579,共3页
Hainan Medical Journal
关键词
帕罗西汀
行为干预
脑卒中后抑郁
Paroxetine
Behavioral intervention
Post-stroke depression
