帕罗西汀与丙米嗪对改善脑卒中后抑郁及神经功能恢复的疗效分析被引量：16

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摘要目的探讨不同抗抑郁药物在改善脑卒中后抑郁及神经功能恢复的疗效。方法随机将95例脑卒中伴抑郁和神经功能障碍患者分为帕罗西汀治疗组(帕罗西汀组)和丙米嗪治疗组(丙米嗪组),动态对比治疗前、4周末、8周末和12周末CNS、HAMA和HAMD评分,用药不良反应等。结果 2组患者在12周末与治疗前对比,P<0.01;在治疗12周末,帕罗西汀组CNS和HAMA评分明显优于丙米嗪组,P<0.01,HAMD评分优于丙米嗪组,P<0.05;帕罗西汀组不良反应发生率4.26%低于丙米嗪组18.75%,P<0.05。结论盐酸帕罗西汀片和盐酸丙米嗪片均能明显改善脑卒中后抑郁症状和促进神经功能恢复,但前者疗效更加确切、不良反应发生率低,且服药方便,药物依从性好。

作者刘献玲

机构地区河南浚县人民医院神经内科

出处《中国实用神经疾病杂志》 2012年第21期83-84,共2页 Chinese Journal of Practical Nervous Diseases

关键词帕罗西汀丙米嗪脑卒中抑郁神经功能

分类号 R743.3 [医药卫生—神经病学与精神病学]

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