摘要
目的:探讨伴印戒细胞分化的原发性乳腺癌的临床特点及预后。方法:回顾性分析天津医科大学附属肿瘤医院1999年2月至2011年6月收治的13例伴印戒细胞分化的原发性乳腺癌患者的临床资料,所有患者均为女性,年龄38～84岁,中位年龄53岁。首发症状多为乳腺肿物。治疗以乳腺癌改良根治术为主,术后辅助放疗、化疗及内分泌治疗。结果:本组13例术后经组织病理学检查均证实为伴印戒细胞分化的原发性乳腺癌,其中临床分期Ⅰ期患者1例,Ⅱ期8例,Ⅲ期4例。术后平均随访53.8个月。3年生存率为46.2%(6/13),5年生存率为30.8%(4/13),10年生存率为7.7%(1/13)。结论:与常见的乳腺浸润性导管癌相比,伴印戒细胞分化的原发性乳腺癌发病率低,侵袭性强,确诊后应积极行手术、放化疗、内分泌等综合治疗。目前尚无可推荐的最佳特异治疗模式,有关研究应继续进行。
Objective： This study aims to analyze the clinical characteristics of primary breast carcinoma with signet-ring cell dif- ferentiation. Methods： Clinical data of 13 patients were analyzed retrospectively. These patients were suffering from primary breast car- cinoma with signet-ring cell differentiation and admitted to Tianjin Medical University Cancer Institute and Hospital between 1999 and 2011. All patients were female with ages ranging from 38 years to 84 years; the median age was 53. The initial symptom in nearly all cases was a single breast mass. Modified radical mastectomy was identified as the treatment of choice. Radiation therapy, chemothera- py and endocrine therapy consisted the postoperative adjuvant therapy. Results： Histopathological examination after surgery confirmed the diagnosis for 13 cases of primary breast carcinoma with signet-ring cell differentiation. From this group, 1 case was in Stage 1, 8 were in Stage Ⅱ, and 4 were in Stage Ⅲ. Follow-ups were conducted for an average of 53.8 months, in which 6 patients were shown to have survived for more than 3 years, 5 for more than 4 years, and only 1 for more than 10 years. The 3-, 5- and 10-year survival rates were 46.2%, 30.8%, and 7.7%, respectively. Conclusion： Compared with the commonly observed infiltrating mammary duct carcino- ma, primary carcinoma with signet-ring cell differentiation exhibits a lower incidence and higher invasiveness. Surgery, radiotherapy, endocrine and other comprehensive treatments should be administered actively after diagnosis. To date, no standard specific guideline has been recommended for clinical practice. Further clinical research relevant to this study should be conducted in the future.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2013年第11期661-663,667,共4页
Chinese Journal of Clinical Oncology
关键词
伴印戒细胞分化的癌
乳腺癌
临床特征
carcinoma with signet-ring cell differentiation, breast cancer, clinical characteristics
