摘要
目的：研究浸润性小叶癌（ＩＬＣ）的各种组织类型特点。方法：对７５３例浸润性乳腺癌存档资料进行回顾性分析。结果：在７５３例浸润性乳腺癌中ＩＬＣ４３例（占５．７１％），复查前后对ＩＬＣ诊断误差率为９３．０２％。该组ＩＬＣ平均年龄５１．２岁，肿瘤平均直径３．５ｃｍ，有腋下淋巴结转移者２５例（５８．１３％）。按ＩＬＣ组织形态可分出１０个亚型：经典型１３例（３０．２３％），腺泡型６例（１３．９５％），多形型４例（９．３０％），实性型３例（６．９７％），印戒细胞型２例（４．６５％），粘液型２例（４．６５％），小梁型１例（２．３２％），小管型１例（２．３２％），混合型６例（１３．９６％）和小叶－导管复合型癌５例（１１．６２％）。结论：ＩＬＣ组织学形态的主要共同特点为：细胞小，癌灶中残留正常小叶单位，细胞呈靶样结构和单列线样排列，有小叶原位癌存在，癌组织呈跳跃式分布，核分裂象和坏死少见。
Purpose In order to understand the feature of every type of infiltrating lobular carcinoma (ILC). Methods The files of the division of surgical pathology for past 31 years were reviewed, and 753 cases of primary breast carcinoma were retrieved. Results Fourtythree of 735 cases of primary breast carcinomas were ILC. There were 9302% for misdiagnosis in the past. The average age of the patients was 512 years and the average size of the tumors was 35 cm. There were 25(5813%) patients with axillary node positive in those cases. On the basis of histological pattern, the tumors were divided into ten variants: 13 cases (3023%) classical type, 6 cases (1395%) alveolar type, 4 cases (930%) pleomorphic type, 3 cases (697%) solid type, 2 cases (465%) signetring cell type, 2 cases (465%) mucous type, 1 case (232%) trabecular type, 1 case (232%) tubular type, 6 cases (1396%) mixed type and 5 cases lobularductal combinative type. Conclusions In those cases, the common morphologic features include small tumor cells, the persistence of normal lobularunit within ILC, a targetoid pattern, cells in single file arrangement, the presence of lobular carcinoma in situ and the skip areas foci of infiltrating carcinoma separated by uninvolved mammary tissue. Also, the tumors have fewer necrosis and mitosis figures.
出处
《临床与实验病理学杂志》
CAS
CSCD
1998年第1期16-19,I003,共5页
Chinese Journal of Clinical and Experimental Pathology
关键词
乳腺癌
浸润性小叶癌
病理学
分类
breast neoplasms
infiltrating lobular carcinoma
pathological classification
