摘要
目的探讨艾司西酞普兰（ESC）联合醒脑静治疗脑卒中后抑郁的临床疗效。方法将74例脑卒中后抑郁患者按随机数字表法分为治疗组（38例，给予ESC联合醒脑静治疗）和对照组（36例，给予ESC治疗）。比较两组患者汉密尔顿抑郁量表（HAMD）、简易精神状态检查（MMsE）、记忆商（MQ）及日常生活活动能力（ADL）评分，临床疗效，不良反应。结果对照组和治疗组治疗后HAMD、MMSE、MQ、ADL评分均较治疗前显著改善[对照组：（14．26±2．61）分比（29．73±5．17）分、（23．26±3．75）分比（21．24±3．38）分、（86．53士6．49）分比（82．35±5．42）分、（61．37±3．72）分比（45．32±4．48）分，治疗组：（10．31±2．08）分比（29．57±6．09）分、（27．83±4．31）分比（21．63±3．82）分、（95．63±6．41）分比（82．30±7．48）分、（69．15±6．39）分l：t（45．27±4．28）分]，差异有统计学意义（P〈0．05）；且治疗组治疗后均显著优于对照组，差异有统计学意义（P〈0．05）。治疗组总有效率显著高于对照组[97．4％（37／38）比86．1％（31／36）]，差异有统计学意义（P〈0．05）。两组不良反应发生率比较差异无统计学意义（P〉0．05）。结论ESC联合醒脑静治疗脑卒中后抑郁，疗效确切，安全性好。值得临床进一步应用推广。
Objective To explore the clinical effect of escitalopram combined with xingnaojing in post-stroke depression （PSD）. Methods Seventy-four cases with PSD were divided into treatment group （38 cases） and control group （36 cases） by random digits table,control group was given escitalopram, treatment group was given escitalopram and xingnaojing. Hamilton depression scale （HAMD）, mental state examination （ MMSE ）, memory quotient （MQ） and activities of daily life （ADL） score, clinical curative effect and adverse reaction were compared between 2 groups. Results The HAMD, MMSE, MQ,ADL score after treatment in 2 groups were significantly better than those before treatment [control group： （14.26 ± 2.61 ） scores vs. （29.73 ± 5.17 ） scores, （23.26 ± 3.75 ） scores vs. （21.24 ± 3.38 ） scores, （86.53 ±6.49 ） scores vs. （82.35 ± 5.42） scores, （61.37 ± 3.72） scores vs. （45.32 ± 4.48） scores;treatment group： （10.31 ± 2.08） scores vs. （29.57 ± 6.09） scores, （27.83 ± 4.31 ） scores vs. （21.63 ± 3.82） scores, （95.63 ± 6.41 ） scores vs. （82.30 ± 7.48） scores, （69.15 ± 6.39） scores vs. （45.27 ± 4.28） scores,P 〈 0.05]. The HAMD,MMSE, MQ, ADL score after treatment in treatment group were significantly better than those in control group （P 〈 0.05）. The total effective rate in treatment group was significantly higher than that in control group [97.4% （37/38） vs. 86.1%（31/36）, P 〈 0.05 ]. There was no significant difference in rate of adverse reaction between 2 groups （P 〉 0.05 ）. Conclusion Escitalopram combined with xingnaojing in PSD is effective and safe, and worth further clinical application promotion.
出处
《中国医师进修杂志》
2013年第15期23-25,共3页
Chinese Journal of Postgraduates of Medicine
关键词
脑血管意外
抑郁
艾司西酞普兰
醒脑静
Cerebrovascular accident
Depression
Escitalopram
Xingnaojing
