摘要
目的分析肝细胞癌(HCC)自发消退的发生规律。方法对MEDLINE进行检索,获取自1982年以来HCC自发消退的病例85例,对所得病例资料进行分析,并与HCC的流行病学特点进行比较。结果 HCC自发消退发生概率可能比之前估计的要高,其多发生于酒精所致的HCC患者,而与患者的种族、年龄、性别及肿瘤的分化程度和进展程度可能无明显关联;导致HCC自发消退的最可能的原因为免疫因素。结论 HCC自发消退的发生可能是外界微环境或条件改变的结果,而与肿瘤细胞自身的生物学属性可能无关;深入探讨其发生机制有可能开辟HCC治疗的新方向。
Objective To investigate the regularity of spontaneous regression of hepatocellular carcinoma （HCC）. Methods A total of 85 eases of HCC spontaneous regression of HGC were obtained through searching in MEDLINE. All clinical data were analyzed and compared with HCC epidemiological characteristics. Results The probability of HCC spontaneous regres- sion incidence was higher than previously estimated. It mostly occurred in alcohol - caused HCC patients, not obviously correla- ted with patients＇ kind, age, gender, tumor differentiation and its progression. The most probable cause leading HCC spontane- ous regression were immune factors. Conclusion Spontaneous regression of HCC maybe be a result of changes of external micro - environment or conditions, not correlated with the biological properties of tumor cells. Deep exploration for its mechanism may open up an entirely new approach to HCC direction.
出处
《中国全科医学》
CAS
CSCD
北大核心
2013年第14期1575-1577,共3页
Chinese General Practice
关键词
癌
肝细胞
肿瘤消退
自行性
流行病学
免疫
Carcinoma, hepatocellular
Neoplasm regression, spontaneous
Epidemiology
Immunity
