摘要
目的评价癫痫患者的质量调整生命年(QALY)及其影响因素。方法采用多阶段分层随机抽样的方法,于2005年1月—2011年7月在河南省焦作市的孟州市、修武县,漯河市的郾城区、源汇区、舞阳县、临颍县、召陵区,南阳市的新野县和方城县9个项目示范点,采用癫痫患者生存质量量表和抑郁自评量表对874例癫痫患者(分为干预组、对照组)的多个指标进行测量,利用R 2.10.0对QALY及其影响因素进行单因素和多因素分析。结果本研究地区癫痫患者人均获得的QALY为21.24年。经过综合干预的癫痫患者获得的QALY(27.95)高于对照组(14.98),差异有统计学意义(P<0.05)。年龄、病程、发病年龄、发作频率和焦虑状况是患者QALY的危险因素,服单药和依从性好是QALY的保护因素。结论今后应针对重点人群、重点的可干预影响因素加强干预,以规范治疗+随访管理与健康教育+心理干预治疗为主要手段的综合干预措施是切实可行的。
Objective To evaluate the quality adjusted life years （QALYs） and its influencing factors in patients with epilepsy. Methods We used a multi - stage random sampling method to select patients of epilepsy from nine counties/districts of Henan Province. The subjects were divided into a study group and a control group based on their inclusion into a government funded comprehensive management program which encompassed standardized treatment, follow - ups, health education, and psychological intervention. Quality of Life （QOL） Scale and Self - rating Depression Scale （SDS） were used to measure the mul- tiple indicators. Software R 2. 10. 0 was used for univariate and multivariate analyses to evaluate QALY and its influencing fac- tors. Results Altogether 874 patients of epilepsy were included in this study, with 422 in the study group and 452 in the control group. The overall QALY of all subjects was 21.24 per person. The average QALY of the study group （27.95） was longer than that of the control group （ 14. 98） （P 〈0. 05） . Age, disease duration, age at onset, seizure frequency and anxiety status were risk factors of QALY of patients with epilepsy, single medication and good compliance were protective factors of QALY. Conclu- sion This comprehensive management program for patients with epilepsy is effective and its application should be spread.
出处
《中国全科医学》
CAS
CSCD
北大核心
2013年第13期1506-1509,共4页
Chinese General Practice
基金
卫生部中央补助地方农村地区癫痫防治管理项目(财社[2006]126号)
河南省医学重点学科
临床特色专科学术技术带头人培养计划项目(201018-66)
关键词
癫痫
质量调整生命年
影响因素
Epilepsy
Quality adjusted life years
Influencing factors
