摘要
目的探讨慢性乙型肝炎中医证型与临床单一生化指标的关联性。方法选择慢性乙型肝炎肝胆湿热证和肝郁脾虚证患者各200例,观察两组患者血清TBIL、DBIL、TBA含量,血清ALT、AST、GGT、ALP活性,血清总蛋白、白蛋白含量及血清蛋白电泳等指标的变化。结果不同证型的慢性乙型肝炎患者,血清TBIL、DBIL、TBA含量,血清ALT、AST、GGT、ALP活性,血清总蛋白、白蛋白含量组间比较差异无统计学意义(P>0.05),血清蛋白电泳组间比较差异亦无统计学意义(P>0.05)。结论慢性乙型肝炎肝功能、血清蛋白电泳等单一疾病指标与中医证型无关联性;本研究提示作为整体功能变化表现的中医"证候",其生物学基础研究应从"指标群组合"入手的研究思路。
Objective To explore the relevance between chronic hepatitis B（CHB） TCM types and clinical biochemical markers. Methods We selected patients who were corresponding to diagnosis on chronic hepatitis B standards,with syndrome of dampness - heat of liver and gallbladder and syndrome of stagnation of liver qi and spleen deficiency with 200 cases for each. And the changes of serum TBIL, DBIL,TBA content, serum ALT,AST, GGT, ALP activity, serum TP, ALB and serum protein electrophoresis indexes of two group were observed. Results There was no significant difference between the patients of two TCM types in serum TBIL, DBIL,TBA content, serum ALT, AST, GGT, ALP activity and serum TP, ALB （P 〉 0. 05 ）. There was no significant difference between the patients of two TCM types in serum albumin,α globulin, α2 globulin, β globulin, γglobulin too（P 〉 0. 05）. Conclusion There were no relevance between chronic hepatitis B TCM type and single clinical biochemical markers of liver function indexes and serum protein electrophoresis. The study provides the idea for that the research on the biology basis of Chinese syndrome which changes as an overall function should start with investigation and study from ＂combination of index group＂.
出处
《医学研究杂志》
2013年第5期106-109,共4页
Journal of Medical Research
基金
肝肾疾病病证教育部重点实验室开放基金资助项目(GS090201)
关键词
慢性乙型肝炎
中医证候
临床生化指标
关联性
Chronic hepatitis B
TCM syndromes
Clinical biochemical markers
Relevance
