老年蛛网膜下腔出血患者脑脊液和血清中细胞因子水平的变化被引量：1

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摘要目的探讨老年蛛网膜下腔出血(SAH)患者脑脊液和血清中细胞因子的表达及关系。方法选择53例老年SAH患者作为病例组并按病情及是否发生CVS分组,选择同期老年健康体检者50例作为对照组,ELISA法检测脑脊液和血清中细胞因子包括白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)的表达。结果病例组脑脊液和血清中IL-6和TNF-α表达明显高于对照组(P<0.05),且随着病情恶化,其表达也有升高趋势;细胞因子在SAH后CVS组的表达显著高于非CVS组(P<0.05);病例组血清IL-6和TNF-α表达分别与脑脊液呈明显正相关(P<0.05)。结论老年SAH发生时,患者脑脊液和血清细胞因子的表达显著增高,并且二者表达有密切的关系,共同参与SAH的发生发展。

作者姜建强赵旭伟郭知伟杨俊杰王宝庆陈玉军

机构地区齐齐哈尔医学院第一附属医院

出处《中国老年学杂志》 CAS CSCD 北大核心 2013年第10期2288-2289,共2页 Chinese Journal of Gerontology

关键词蛛网膜下腔出血血清脑脊液细胞因子

分类号 R743 [医药卫生—神经病学与精神病学]

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参考文献7

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