摘要
目的探讨微粒体环氧化物水解酶编码基因EPHX1多态性与肝细胞性肝癌(HCC)遗传易感性的关系。方法按照制定的检索策略,检索相关数据库中的文献,获取有关EPHX1基因多态性与HCC易感性的病例-对照研究,提取相关数据进行Meta分析。以病例组和对照组基因型分布的比值比(OR)为效应指标,对纳入文献进行异质性检验,应用Stata12.0软件以不同合并模型对各研究原始数据进行Meta合并,计算合并效应量OR值及其95%可信区间(CI)。结果共纳入9篇文献,EPHX1337T>C多态位点的共8个研究,累计病例584例,对照989例。等位基因比较模型(CvsT)的OR值为1.47(95%CI=1.26～1.72,P<0.001);纯合子比较模型(CCvsTT)的OR值为1.88(95%CI=1.40～2.52,P<0.001);隐性模型(CCvsCT/TT)的OR值为1.73(95%CI=1.36～2.21,P<0.001)。EPHX1416A>G多态位点共6项研究,累计病例432例,对照699例。等位基因比较模型(GvsA)的OR值为0.75(95%CI=0.59～0.95,P=0.018)。结论 EPHX1337T>C多态位点CC基因型与HCC易感性升高有关;416A>G多态位点等位基因G可能降低HCC易感性,为保护基因型。
Objective To explore the relationship between microsomal epoxide hydrolase（EPHXl ）polymml）hism and genetic sus- ceptibility to hepatocellular careinoma（HCC）. Methods Both English- and Chinese-language databases were searched for relevant literature on the relationship between EPHX1 polymorphism and HCC using a preformulated search strategy.Data on the association were evaluated using odds ratio（ORs）with 95% confidenee intelwals（CIs）, and heterogeneity of included studies was assessed. Metaanalysis of published data was carried out using Siata 12.0 software. Results Nine studies were included based on the selection criteria 8 studies,involving 584 cases and 989 controls,examined the EPHX1 polymorphism 337T〉C.Signi[icant increased risk of HCC was found using the additive model[C vs T OR（95%CI）=1.47（1.26-1.72） ,P〈0.001 ] ,homozygole comparison[CC vs TT OR（95%CI） =1.88（1.40-2.52） ,P〈0.001 ] ,and the recessive model[ CC vs CT/TT OR（95%CI）=1.73（ 1.36-2.21 ）,P〈0.001 ].A total of 6 studies involving 432 cases and 699 controls examined the EPHXI polymorphism 416A〉G.Markedly decreased risk of HCC was observed using the additive model [ G vs A OR（95%C1 ）=0.75 （0.59-0.95）,P=0.018 ]. Conclusions The EPHX 1 polymorphism 337T〉C is associated with HCC,and the CC genotype appears to be a risk tactor.In contrast,the G allele of the EPHX1 polymorphism 416A〉G may decrease HCC susceptibility and therefore constitute a protective factor against HCC.
出处
《中国癌症防治杂志》
CAS
2012年第3期263-267,共5页
CHINESE JOURNAL OF ONCOLOGY PREVENTION AND TREATMENT
关键词
肝肿瘤
微粒体环氧化物水解酶
EPHX1
遗传多态性
肿瘤易感性
Hepatocellular neoplasms
Microsomal epoxide hydrolase
EPHX 1
Genetic polymorphism
Cancer susceptibility
