摘要
目的探讨侵袭性淋巴瘤18F标记的氟代脱氧葡萄糖（18F-FDG）摄取程度与核抗原Ki-67表达的关系。方法回顾性分析77例侵袭性淋巴瘤初诊患者的18F-FDG正电子发射计算机体层摄影（PET-CT）扫描资料和免疫组化检测结果。采用最大标准摄取值（SUVmax）和平均标准摄取值（SUVave）衡量18F-FDG摄取程度。由计算机工作站获得每例患者全身病灶的SUVmax（BmSUVmax）、活检部位病灶的SUVmax（BxSUVmax）和SUVave（BxSUVave）。结果77例侵袭性淋巴瘤患者的BmSUVmax、BxSUVmax和BxSUVave分别为13．4±6．8、11．9±6．8和7．3±4．4，Ki-67表达为（61．2±20．4）％。BmSUVmax高于BxSUVmax（P〈0．001），BxSUVmax高于BxSUVave（P〈0．001）。其中BmSUVmax、BxSUVmax、BxSUVave与Ki-67表达呈正相关（P〈0．05），BmSUVmax与BxSUVmax、BxSUVmax与BxSUVave呈正相关（均P〈0．05）。弥漫大B细胞淋巴瘤的BmSUVmax、BxSUVmax与Ki-67表达无关（均P〉0．05）。结外NK／T细胞淋巴瘤（鼻型）的BmSUVmax、BxSUVmax与Ki-67表达呈正相关（均P〈0．05）。结论侵袭性淋巴瘤的18F-FDG摄取程度与Ki-67表达相关，BmSUVmax可弥补组织学活检的局限性；结外NK／T细胞淋巴瘤（鼻型）的18F-FDG摄取程度与Ki-67表达关系密切，提示18F-FDG摄取程度可能会提供预后信息并指导治疗。
Objective To investigate the correlation between 18F-FDG uptake in positron emission tomography/computed tomography imaging and tumor-proliferating antigen Ki-67 expression in aggressive lymphoma. Methods Data of 18F-FDG PET-CT imaging and immunohistochemical detection of Ki-67 expression of seventy-seven cases with initially diagnosed aggressive lymphoma were retrospectively analyzed. The intensity of 18F-FDG accumulation was determined by calculating the maximum standardized uptake value （SUVmax） and average standardized uptake value （SUVave）. The average SUV at biopsy site （BxSUVave）, SUVmax at biopsy site （BxSUVmax） and SUVmax at the highest tumor activity site of the body （BmSUVmax） were collected. Results The BmSUVmax, BxSUVmax, and BxSUVave were 13.4 ± 6.8, 11.9 ± 6.8 and 7.3 ± 4.4, respectively, and Ki-67 was （61.2 ± 20.4 ） % in the 77 aggressive lymphomas. The BmSUVmax was significantly higher than the BxSUVmax or BxSUVave （ P 〈 0.05 ）. The BmSUVmax, BxSUVmax and BxSUVave were positively correlated with the Ki-67 expression in aggressive lymphoma （P 〈 0.05）. A positive correlation was revealed between the BxSUVmax and BmSUVmax （P 〈 0.05）, and between the BxSUVmax and BxSUVave （ P 〈 0.05 ）. No significant correlation was found between the BmSUVmax or BxSUVmax and the Ki-67 in DLBCL （P 〉 0.05 ）. A positive correlation was observed between the BmSUVmax or BxSUVmax and the Ki-67 expression in NK/T cell lymphoma （ P 〈 0.05）. Conclusion The increasing trend of 18F-FDG uptake is correlated with the Ki-67 expression in aggressive lymphoma. The results of this study suggest that the metabolic information obtained by usingBmSUVmax may help to compensate the limited sampling of histological examination at the biopsy site. Significant correlation in NK/T cell lymphoma suggests that the metabolic information from positron emission tomography-computed tomography may offer a useful parameter in the prognosis and management of this disease.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2013年第5期356-360,共5页
Chinese Journal of Oncology
