摘要
目的:探讨超分割放射治疗鼻咽癌对视神经功能的影响。方法:98例鼻咽癌患者随机分入超分割放疗组(研究组)和常规放疗组(对照组),全部患者于放疗前后予视力视野及电生理学检查。结果:两组患者放疗后均可出现放射性视神经损伤,研究组和对照组放疗后第24个月参照RTOG标准视神经损伤发病率分别为5.0%和23.8%,视觉诱发电位检查潜伏期异常发生率分别为15.0%和35.7%,两组间放射性视神经损伤发生率及损伤程度均存在明显差异。结论:超分割放疗能明确减低放射性视神经损伤的发病率及严重程度,改善患者的生活质量。
Objective. To investigate the effect of targeting radiotherapy of nasopharyngeal carcinoma （NPC） on the optic neuropathy after radiation therapy. Methods： 98 NPC patients were randomly assigned to the hyperfractionated radiotherapy （the experimental group） and conventional fractiona- tion radiotherapy （the control group）. All patients received the ophthalmologic evaluation and VEP tests before and after radiation therapy. Results： Of the all patients in the study, 12 developed the optic neuropathy. The experimental group, 2 （5.0%） developed the optic neuropathy compared to 10 （23.8%） in the control group. The experimental group had a lower incidence rate of the latency of VEP than the control group （15.0%VS 35.7%）. The data showed a decrease in the occurrence of optic neuropathy after hyperfractionation compared with the conventional fractionation radiother- apy. Conclusion： Hyperfractionated radiotherapy can obviously reduce the incidence rate of optic neuropathy and severity degree, and improve the patients＂ quality of lives.
出处
《华夏医学》
CAS
2013年第1期37-40,共4页
Acta Medicinae Sinica
基金
广西壮族自治区卫生厅科研课题基金资助(Z2008283)
关键词
鼻咽癌
超分割
放射治疗
视神经
nasopharyngeal carcinoma
hyperfractionated radiotherapy
optic nerve
