摘要
目的观察补肾活血中药对药物性听力损害的保护作用。方法应用耳廓反射、听性脑干反应及耳蜗基底膜铺片技术研究了补肾活血复方对豚鼠卡那霉素（KM）耳蜗毒性的拮抗作用。结果服用补肾活血复方的豚鼠注射KM后较单纯肌注KM组的豚鼠听力损害轻，且耳蜗外毛细胞损害的程度办明显减轻，说明补肾活血复方中药对氨基糖俄类抗生素所造成的听力损害具有一定的保护作用。结论为临床上运用补肾活血法防治药物中毒性聋提供了实验依据。
Objective To observe the antiototoxicity of the complex prescritions of Invigo-rate kidney and promote blood circuIation to remove blood stasis on kanamicin (KM) in guiniaplgs. Method The techniques of preyer's reflex (PR), auditory brainstem response (ABR) andputting the basilar membrane of cochlea on sheet glass were used. Result After injections ofKM, the hearing loss and the damage to cochlea outer hair cells of the guinia pigs taked the com-plex prescriptions of Invigorate kidney and promote blood circulation to remove blood stasis werellghtened obvlously than the control group- Conclusion It proved the protection of drugs of In-vigorate kidney and promote blood circulation to remove blood stasis against hearing loss byamlnosuger antibiotic. This study provided experimental basls for the method of Invigorate kid-ney and promote blood circulatio to remove blood stasis preventing and treating ototoxic deaf-ness.[
出处
《中国中西医结合耳鼻咽喉科杂志》
2000年第3期105-107,共3页
Chinese Journal of Otorhinolaryngology in Integrative Medicine
基金
广东省中医药管理局资助!96099
关键词
补肾药
活血药
卡那霉素
毒性
药物性听力损害
Invigorate kidney drugs Drugs of promote blood circulation to remove blood stasis Kanamicin/toxicity
