摘要
目的:观察小槐花醇提物的药理作用。方法:采用对戊巴比妥钠小鼠睡眠时间的影响实验;小鼠醋酸扭体法;小鼠碳末廓清法和对正常小鼠血清SOD活性和MDA含量的影响实验,以及急性毒性试验。结果:小槐花醇提物能促进小鼠睡眠并延长其睡眠时间,减少醋酸所致的小鼠扭体反应次数,能提高单核巨噬细胞吞噬指数,能有效降低小鼠血清MDA含量,同时提高SOD活性。小鼠最大给药量为128g生药/kg。结论:提示小槐花醇提物具有明显的镇静催眠,镇痛,免疫增强和抗氧化作用,且毒性较低。
Objective: To observe the pharmacological function of Flos Sophorae extract.Methods: Sodium pentobarbital induced mice’s sleeping time test,acetic acid writhing mice test,mice carbon clearance method and normal mouse serum SOD activity test,MDA content test and the acute toxicity test were used.Results: Flos Sophorae extract could promote and prolong the mice sleeping time,reduce the writhing times caused by acetic acid,enhance the index of high mononuclear macrophage phagocytosis,effectively reduce the content of MDA in serum of the mice,and increase the activity of SOD.The mice maximum dosage was 128G crude drug / kg.Conclusion: Flos sophorae alcohol extract has obvious sedative,hypnotic,analgesic,immune and antioxidant effects,with low toxicity.
出处
《云南中医中药杂志》
2013年第5期64-65,89,共2页
Yunnan Journal of Traditional Chinese Medicine and Materia Medica
基金
广西自然科学基金项目(NO:2012GXNSFAA053175)
关键词
小槐花醇提物
药理作用
小鼠
Flos sophorae alcohol extract,pharmacological action,mice
