摘要
目的:探讨中药肺痿冲剂方治疗特发性肺纤维化3月后胸部高分辨CT(HRCT)半定量评分及相关肺功能指标的影响。方法:选取2009年5月至2010年6月在我院诊断的特发性肺间质纤维化患者,随机分成肺痿冲剂方治疗组和金水宝对照组,治疗组口服肺痿冲剂方汤剂,对照组口服金水宝胶囊,疗程6个月,选取HRCT、肺功能等资料完整者6例最后进行分析。结果:两组治疗前后VC、FVC、FEV1/FVC、TLC、DLco、Dlco/VA、PO2、PCO2、6MWT等比较,差异均无统计学意义,CT评分两组比较,磨玻璃影、实变、蜂窝肺等前后差异无统计学意义,但幸免区域两组治疗前后差值比较治疗组变化较明显(P=0.046),总评分有差异趋势(P=0.05)。结论:肺痿冲剂方短期治疗对特发性肺纤维化患者CT评分改善有一定效果,仍需进一步研究观察。
Objective： To observe the Semi-quantitative score and pulmonary fuction variation of chest high-resolution computed tomography （HRCT） after 3 months treatment of TCM Feiwei Chongji Formula. Methods： 20 patients with idiopathic Pulmonary fibrosis from May 2009 to June 2010 were randomly divided into treatment group and control group. The treatment group were treated with ＇Feiwei Chongji Formula＇, and the control group were with paecilomyces hepiall chen for six months. Six IPF patients with integrated data were finally analysed. Results： After 3 months of treatment, there was no statistical significant difference in both groups in the pulmonary function index as VC, FVC, FEV1/FVC, TLC, Dlco/VA, PO2, PCO2 and 6 minute Walk test （6MWT） variation comparison. There was no statistical significant difference in HRCT scores variation in ground- glass opacity （GGO）, consolidation and honeycomb lung of IPF lesion. But in the shave area of IPF lesion variation comparison, treatment group displayed statistical significance superiority （P=0.046）, total Semi-quantitative scores of HRCT in experiment group exhibited difference tendency （P=0.05）. Conclusion： Shortterm therapy of Feiwei Chongji Formula had some effect in improvement of Semi-quantitative HRCT scores in patients with IPF, but more reliable conclusion still needs further observation.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2013年第6期1896-1898,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家中医药管理局2008年行业专项(No.200807046)~~
关键词
肺痿冲剂方
特发性肺纤维化
高分辨率CT
Feiweichongji Formula
Idiopahtic pulmonary fibrosis
High-resolution computed tomography
