摘要
目的 研究骨质疏松症对种植体周围骨量及骨结合的影响。方法 于 32周龄Wistar雌性大白鼠胫骨骨骺端植入羟基磷灰石 (HA)种植体 ,术后 5 6d实验组行卵巢摘除术 ,对照组行假手术。该术后 2 8、84、16 8d分别处死动物取胫骨 ,制作研磨切片标本 ,应用骨形态测量学技术探讨种植体周围单位骨量及与新生骨接触面积率的动态变化。结果 卵巢摘除术后 2 8d ,实验组单位骨量与对照组比较 ,差异有显著性 ;骨皮质部骨与种植体接触面积率 ,两组之间差异无显著性。骨松质部骨与种植体的接触率 ,在 84d以后实验组与对照组比较差异有显著性。结论 骨质疏松症由于支持种植体周围的骨小梁疏松 ,是种植牙预后的不利因素 ,有必要慎重观察闭经女性种植体的临床经过。
Objective To investigate the effects of estrogen decreasing on bone tissues around implants in ovariectomized rats. Method Forty-two female Wistar rats, aged 32 weeks, were used in this study. First, cylindrical hydroxyapatite-coated implants were planted in the proximal part of tibiae of the rats. Then, the rats in experimental group and control group were respectively performed ovariectomy and false surgery after 56 days, the rates were killed in 28, 84 and 168 days after operation, and tibiae were taken out to prepare undecalcified sections. The section were examined by routine histomorphometric measurement and the dynamic changes of trabecular bone and extent of contact between the implants and bone tissue around them. Results Twenty-eight days after operation, the density of trabecular bone around the implant in experiment group was found significantly reduced compared with the control group. In the area of cortical bone, no difference was found in the extent of implant-bone contact between two groups, while in the area of spongy bone the extent of contact was different obviously. Conclusion Ovariectomy in Wistar rats can induce significant osteoporosis around implant, these finding suggest that menopause in women patients may also induce osteoporosis around implanted artificial teeth and affect the prognosis. Therefore, the patients should be carefully observed during the implant treatment course.
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
2000年第5期362-364,共3页
Chinese Journal of Stomatology
