摘要
目的：研究食管鳞癌(esophageal squamous carcinoma,ESC)组织中一氧化氮合酶(nitric oxide synthase,NOS)的活性与ESC生物学行为之间的关系，探讨NOS与ESC组织分化程度、TNM分期、淋巴结转移和预后的关系。方法：采用免疫组织化学法检测65例ESC和53例癌旁组织中NOS1、NOS2、NOS3的表达。结果：NOS1在低、中分化组的阳性率明显高于高分化组(P<0.05)；NOS3的阳性率在低中分化组、淋巴结转移组中分别明显高于高分化组、无淋巴结转移组(P<0.05)；NOS3在Ⅱb期和Ⅲ期组的阳性率明显高于Ⅰ期和Ⅱa期组(P<0.05)，且NOS3阴性者的2年生存率明显高于阳性者(P=0.04)。结论：ESC组织的分化程度、TNM分期、淋巴结转移情况和预后与NOS尤其是NOS3有密切关系。NOS的检测可作为ESC生物学行为和预后评价的参考指标。
Objective： To investigate expression of nitric oxide synthase (NOS) in esophageal squamous carcinoma (ESC) and the relationship between the expression and the biological behaviors of ESC. Methods： The NOS1, NOS2 and NOS3 expression in ESC was detected by immunohistochemistry (65 cases) . Results： The expressive rate of NOS1 in of low mediately differentiated case was significantly higher than that in well differentiated case (P< 0.05). The expressive rates of NOS3 in low mediately differentiated group, stageⅡ b and Ⅲ , and lymphoid metastatic group was significantly higher than those of well differentiated group, stageⅠ andⅡ a, and non lymphoid metastatic group, respectively (P< 0.05). And the patient with NOS3 positive ESC had a worse prognosis than those negative ones (P=0.04). Conclusion： The expression of NOS, especially NOS3, has close relationship with the differentiation, TNM stage, lymphoid metastasis and prognosis of ESC.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2000年第9期936-938,共3页
Chinese Journal of Cancer
基金
本课题受中山医科大学孙逸仙纪念医院科研启动基金
