摘要
目的：探讨细胞周期调节因子异常表达对鼻咽癌复发间期的影响。方法：采用LsAB法检测原发鼻咽癌组织p53、MDM2、WAF1和Ras蛋白的表达。结果：p53或MDM2蛋白高表达的鼻咽癌患者的复发间期，比相应蛋白的低表达和阴性者明显缩短，两调节因子无论在单因素分析（分别P<0.05和P<0.005）或多因素分析（分别P=0.0338和P=0.0003）均有统计学的显著差异。结论：p53和MDM2蛋白高表达提示有促进鼻咽癌复发的作用；两蛋白分别是影响鼻咽癌复发间期的独立因素，可以作为预测鼻咽癌复发倾向和患者预后的参考指标。
Objective： To explore influence of cell cycle regulators on relapse interval of nasopharyngeal carcinoma(NPC). Method： The expressions of p53, MDM2, WAF1 and Ras proteins were determined in primary NPC tissues by LsAB immunohistochemical technique. Results： The relapse interval of NPC patient with high p53 or MDM2 protein expression was shorter than that of with low and negative expression (P< 0.05 and P< 0.005 by univariate analysis, P=0.0338 and P=0.0003 by multivariate analysis, respectively). Conclusion： These results suggest that the high expression of p53 or MDM2 protein may play a promoting role in NPC relapse, p53 and MDM2 proteins are two independent factors affecting relapse interval of NPC. They may serve as markers predicting the trend of NPC s progress and patient s prognosis.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2000年第9期876-878,共3页
Chinese Journal of Cancer
基金
本课题受卫生部科学研究基金项目!(96-2-076)
关键词
鼻咽肿瘤
P53蛋白
MDM2蛋白
RAS蛋白
肿瘤复发
： Nasopharyngeal neoplasm
p53 protein
WAF1 protein
MDM2 protein
Ras protein
Neoplasm relapse
