摘要
目的:探讨雷公藤多苷联合激素治疗儿童紫癜性肾炎(HSPN)的临床疗效及对凝血功能的影响。方法 :将74例HSPN患儿随机分为两组,对照组(37例)采用泼尼松治疗,治疗组(37例)采用泼尼松联合雷公藤多苷治疗。比较分析两组的临床疗效、凝血功能及不良反应。结果 :观察组的总有效率为86.5%,显著高于对照组64.9%(P<0.05);观察组和对照组激素疗程分别为(21.5±4.2)d,(39.2±5.7)d,差异有统计学意义(P<0.05)。治疗后,两组的凝血功能指标均有所改善,而观察组APTT、PT、FIB及DD与对照组比较,差异有统计学意义(P<0.05)。观察组的不良反应较对照组轻。结论 :雷公藤多苷联合激素治疗儿童HSPN安全有效,可缩短激素使用疗程,降低高凝状态,不良反应少。
Objective ： To explore the clinical effect and its influence on coagulation of tripterygium glycosides combined with hormone for Henoch-Sehonlen purpura nephritis （ HSPN ） in children. Methods ： 74 cases of HSPN patients were randomly divided into lwo groups.The observation group （ n=37 ） was given tripterygium glycosides and hormone, and control group （ n=37 ） was given hormone alone, respectively. The clinical effect, coagulation and side ettects were observed. ResuIts： The clinical effect in observation group was 86.5%, which was significantly higher than that in control group 64.9% （ P〈0.05 ）.The total taking time of hormone in observation group and control group was （ 21.5 ±4.2 ）d, （ 39.2± 5.7 ）d, and it was statistically different （ P〈0.05 ） .The coagulation in both groups was improved after treatment, while the levels of APTT, PT, FIB and DD in observation group were significantly dift^rent with those in control group （ P〈0.05 ） .The side effects in observation group were fewer than that in control group. Conclusions ： It is effective and safe of Tripterygium glycosides combined with hormone in treating HSPN in children.h can contribute to shorten the treatment course of hormone, and improve coagulation function, and has a relative fewer side effects.
出处
《辽宁中医药大学学报》
CAS
2013年第6期182-183,共2页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
雷公藤多苷
激素
紫癜性肾炎
儿童
凝血功能
Tripterygium glycosides
hormone
Henoch-Sehonlen purpura nephritis
children
coagulalion
