摘要
目的:研究新型药物载体七元瓜环(Q7)对小鼠中枢神经系统和大鼠心血管系统、呼吸系统的影响。方法:考察空白对照(水)组和Q7高、中、低剂量(1.404、0.702、0.351g/kg)组小鼠给药后的自主活动、疼痛、睡眠时间、入睡只数及惊厥情况(n=12);考察正常对照组和Q7高、中、低剂量(0.982、0.491、0.246g/kg)组大鼠给药后的体温、心血管系统和呼吸系统的变化情况(n=6)。结果:与空白对照组比较,Q7高、中、低剂量组小鼠的自主活动、疼痛、睡眠时间、入睡只数及惊厥均无明显差异(P>0.05);与正常对照组比较,Q7高、中、低剂量组大鼠的体温、呼吸频率、呼吸幅度、心率、舒张压、动脉压、心电图PR间期、QRS间期、QT间期和T波均无明显变化(P>0.05)。结论:Q7对小鼠的中枢神经系统和大鼠的心血管系统、呼吸系统均无明显影响。
OBJECTIVE：To investigate the influence of new drug carrier cururbit[7]uril（Q7）on central nervous system of mice and cardiovascular system and respiratory system of rats.METHODS：The autonomic activities,pain,hour of sleep,the number of mice falling asleep and convulsions of mice were investigated in blank control（water）group,Q7 high-dose,medium-dose and low-dose groups（1.404,0.702,0.351 g/kg）after medication（n=12）;the changes of body temperature,cardiovascular system and respiration system in rats were investigated in normal control group,Q7 high-dose,medium-dose and low-dose groups（0.982,0.491,0.246 g/kg）after medication（n=6）.RESULTS：Compared with blank control group,there was no significant difference in autonomic activities,pain,hour of sleep,the number of mice falling asleep and convulsions of mice in Q7 groups（P0.05）;compared with normal control group,the body temperature,the frequency and depth of respiration,heart rate,diastolic blood pressure,arterial pressure,PR,QRS,QT and T-wave had no significant changes in Q7 groups（P0.05）.CONCLUSIONS：Q7 has no significant effects on the central nervous system of mice,neither on cardiovascular system or respiratory system of rats.
出处
《中国药房》
CAS
CSCD
2013年第21期1945-1947,共3页
China Pharmacy
基金
贵州省中药现代化科技产业研究开发专项资助项目(No.黔科合中药字[2009]5035号)
关键词
七元瓜环
一般药理学
中枢神经系统
呼吸系统
心血管系统
小鼠
大鼠
Cururbit[7]uril
General pharmacology
Central nervous system
Respiratory system
Cardiovascular system
Mice
Rats
