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微小核糖核酸21在非小细胞肺癌中的表达及意义 被引量：6

Expression of MicroRNA21 in non-small cell lung carcinoma and its significance
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摘要 目的探讨微小核糖核酸21(miR-21)在非小细胞肺癌组织中的表达及其与临床病理特征的关系。方法应用qRT-PCR方法检测120例非小细胞肺癌标本和120例癌旁肺组织标本中miR-21的表达水平。结果 miR-21在非小细胞肺癌组织中的表达水平明显高于其在癌旁肺组织中的表达水平(P=0.0060)。miR-21的表达情况与非小细胞肺癌患者TNM分期(P=0.0063)、癌细胞分化(P=0.0410)及淋巴结转移(P=0.0197)相关,与性别、病理类型和肿瘤直径无关(均P>0.05)。结论非小细胞肺癌组织中miR-21表达异常提示其可能参与了非小细胞肺癌的发生、发展过程,是一个潜在的非小细胞肺癌分子标志物。 Objective To explore the expression of miR-21 in non-small cell lung carcinoma（NSCLC） tissue and its relationship with clinical pathological features.Methods qRT-PCR was applied to detect the expression of miR-21 in 120 NSCLC tissue specimens and 120 peri-tumor tissues specimens.Results The expression level of miR-21 in NSCLC was higher than that in peri-tumor tissues tissue（P = 0.0060）.The expression of miR21 was related with TNM stage（P = 0.0063）,cancer cells differentiation（P = 0.0410） and lymph node metastasis（P = 0.0197） in NSCLC tissue;which had no relationship with gender,pathological types and tumor diameter（all P 0.05）.Conclusion The abnormal expression of miR-21 in NSCLC tissue indicates that it may play a role in the progression of NSCLC and may be a useful molecular marker for NSCLC.
作者 张哲 魏翔 徐利军
机构地区 华中科技大学同济医学院附属同济医院第二临床学院 华中科技大学同济医学院附属同济医院心脏大血管外科
出处 《中国医药导报》 CAS 2013年第15期132-133,137,共3页 China Medical Herald
关键词 非小细胞肺癌 MICRORNA 微小核糖核酸21 QRT-PCR Non-small cell lung carcinoma microRNA miR-21 qRT-PCR
分类号 R734.2 [医药卫生—肿瘤]
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参考文献16

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二级参考文献9

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同被引文献76

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引证文献6

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中国医药导报
2013年 第15期

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