摘要
目的:研究左归丸加活血化瘀、接骨续筋中药治疗骨质疏松性胸腰椎骨折的临床疗效,为临床用药提供依据。方法:将2010年4月至2012年7月我科骨质疏松性胸腰椎骨折符合肝肾阴虚证的住院患者60例,根据患者进入试验的先后顺序,按随机数字表随机分成2组:A组应用一般抗骨质疏松治疗(密盖息+钙尔奇D+罗钙全)联合左归丸加味方(左归丸+骨碎补、川断、补骨脂、桃仁、红花)治疗,B组应用一般抗骨质疏松治疗(密盖息+钙尔奇D+罗钙全),疗程为2周。于1周后、2周后进行中医症候主要症状疗效判定,治疗前、1周后、2周后及出院时观察患者视觉模拟评分法(VAS)疼痛评分变化,出院时统计便秘发生率、住院时长及住院费用。结果:两组1周后中医症候主要症状疗效判定比较差异无统计学意义(P>0.05),2周后比较差异有统计学意义(P<0.05)。2周后VAS评分比较差异有统计学意义(P<0.05);1周后及出院时VAS评分比较差异无统计学意义(P>0.05)。A组与B组住院时长比较差异有统计学意义(P<0.01);两组住院费用比较差异无统计学意义(P>0.05),两组便秘发生例数比较差异有统计学意义(P<0.05)。结论:左归丸加味方可以减轻骨质疏松性胸腰椎骨折患者的早期疼痛,改善其长期卧床引起的便秘问题,且有效缩短住院时长的同时并没有增加患者的经济负担。
Objective： To the clinical curative of ZuoGuiWan with of study effect integrate efficacy increasing blood circulation, bone continued reinforcement traditional Chinese medicine formula treat osteoporotic thoracolumbar vertebral fractures, providing the basis for the clinical use of drugs. Methods： Sixty cases of osteoporotic thoracolumbar fractures hospitalized patients in line with Yin deficiency of liver and kidney pattern from April 2010 to July 2012 in our department divided into two groups. Generally anti-osteoporosis therapy （Miacalcic with Caltrate D and Rocaltrol） and ZuoGuiWan JiaWei formula （ZuoGuiWan with Drynaria, Radix Dipsaci from Sichuan, psoralea corylifolia, semen persicae, safflower） treatment were used for Group A. Group B used generally anti-osteoporosis therapy （Miacalcic with Caltrate D and Rocaltrol）. Course of treatment was two weeks, assessing the curative effect of the major symptom after one week and two weeks, recording VAS pain score respectively before treatment, one week later, two weeks later and discharge, and record constipation rate, hospitalization duration and cost of hospitalization when discharge from hospital. Results： One week later, major symptom between group A and B had no statistically significant difference （P〉0.05）, but opposite after two weeks （P〈0.05）. Two weeks later, VAS score in patients comparison between group A was less than that of group B （/＇〈0.05）. Both one week later and discharge from hospital, there＇s no statistically significant difference between group A and B. Hospital length difference between Group A and Group B was statistically significant （P〈0.01）. No statistically significant difference between two groups of hospital costs （P〉0.05）. Constipation incidence in two groups was statistically significant （P〈0.05）. Conelusion： ZuoGuiWan JiaWei formula can alleviate latest pain in patients with osteoporotic thoracolumbar fractures, improve their constipation problems due to bedridden and effectively shorten the length of hospitalization and at the same time does not increase the economic burden.
出处
《温州医学院学报》
CAS
2013年第3期191-194,共4页
Journal of Wenzhou Medical College
关键词
骨质疏松
骨折
左归丸
临床研究
osteoporosis
fracture
ZuoGuiWan
clinical research
