摘要
目的探讨结核性脑膜炎脑脊液腺苷脱氨酶检测的临床意义及应用价值,为早期诊断治疗提供参考。方法采用酶显色法检测52例结核性脑膜炎、48例化脓性脑膜炎和45例病毒性脑膜炎患者腺苷脱氨酶水平。结果结核性脑膜炎组、化脓性脑膜炎组、病毒性脑膜炎组腺苷脱氨酶水平分别为(16.51±6.53)、(5.62±2.57)、(3.25±1.3)U/L;结核性脑膜炎组腺苷脱氨酶水平明显高于化脓性脑膜炎组、病毒性脑膜炎组(P<0.05);治疗后2、4、6周腺苷脱氨酶水平明显低于入院时水平,差异有统计学意义(P<0.05);随治疗进展,腺苷脱氨酶水平不断下降(P<0.05)。结论脑脊液中的腺苷脱氨酶测定有助于结核性脑膜炎的早期发现及鉴别诊断,对其进行动态监测可对治疗效果进行评估,指导临床治疗。
OBJECTIVE To discuss the clinical significance and application value of detection of cerebrospinal fluid adenosine in the patients with tuberculous meningitis. METHODS The levels of cerebrospinal fluid adenosine were detected in 52 cases of tuberculous meningitis patients,48 cases of purulent meningitis patients,and 45 cases of viral meningitis patients by using enzyme color method. RESULTS The levels of cerebrospinal fluid adenosine in the tuberculous meningitis group, the purulent meningitis group and the viral meningitis group were （16. 51 ±6.53）U/L, （5.62±2.57）U/L,and （3.25±1.3）U/L, respectively. The level of cerebrospinal fluid adenosine in the tuberculous meningitis group was significantly higher than that in the purulent meningitis group or the viral meningitis group （P〈0.05）. The levels of cerebrospinal fluid adenosine after treatment for 2,4,and 6 weeks were significantly lower than that on the admission, the difference was statistically significant （P〈0.05）;with the development of treatment, the levels of cerebrospinal fluid adenosine were gradually decreased （P〈 0. 05）. CONCLUSION The detection of cerebrospinal fluid adenosine is conducive to the diagnosis and identification of tuberculous meningitis in the early stage, and the treatment effect can be evaluated through the dynamic monitoring so as to guide the clinical treatment.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第10期2513-2514,共2页
Chinese Journal of Nosocomiology
关键词
结核性脑膜炎
脑脊液
腺苷脱氨酶
Tuberculous meningitis
Cerebrospinal fluid
Adenosine
