摘要
目的探讨膀胱移行细胞癌与人乳头状瘤病毒(HPV)16/18型感染的关系,为探索膀胱癌新的治疗预防方案提供科学依据。方法采用第二代杂交捕获技术(HC-Ⅱ)对65例膀胱移行细胞癌组织和30例正常膀胱组织进行HPV感染检测,分析高危HPV16/18感染与膀胱移行细胞癌的关系。结果 65例膀胱癌组织中高危型HPV 16/18检测阳性有42例,阳性率为64.6%,30例正常膀胱组织中高危型HPV16/18检测阳性有2例,阳性率为6.7%;膀胱癌组织中高危型HPV16/18检测阳性率明显高于正常膀胱组织(P<0.05);T2-T4、G3、淋巴结转移组高危型HPV16/18检测阳性率分别明显低于Tis-T1、G1-G2和淋巴结未转移组(P<0.05)。结论 HPV16/18感染可能参与了膀胱移行细胞癌的发病,并对膀胱癌的恶性程度与疾病的进展有一定程度的影响。
OBJECTIVE To investigate the relationship between the human papillomavirus 16/18 infections and the bladder cancer so as to provide scientific basis for exploring the prevention and treatment programs for the bladder cancer. METHODS The second generation hybrid capture technology （HC- Ⅱ ） was used for the detection of HPVs infections in 65 bladder cancer patients and 30 participants with normal bladder tissues ,and the correlation between the high-risk HPV16/18 infections between the bladder cancer was analyzed. RESULTS The positive rate of high risk HPV16/18 infections was 64. 6% （42 cases）in 65 bladder cancer patients and was 6. 7% （2 cases）in 30 participants with normal bladder tissues, the positive rate of the high risk HPV16/18 infections was significantly higher in the patients with bladder cancer than in the participants with normal bladder tissues （P^0.05）. The positive rate of the high risk HPV16/18 infections was significantly lower in the patients with metastasis of lymph node, T2-T4 or G3 than in the participants without metastasis of Tis-T1, G1-G2, or lymph node. CONCLUSION The HPV 16/18 infection may involve in the pathogenesis of the bladder cancer and has certain impact on the malignancy and progress of the bladder cancer.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第10期2282-2283,2301,共3页
Chinese Journal of Nosocomiology
关键词
膀胱肿瘤
人乳头状瘤病毒
第二代杂交捕获技术
Bladder neoplasm
Human papilloma virus
Second generation hybridization capture Ⅱ
