摘要
目的:探讨神经节苷脂联合高压氧治疗新生儿缺血缺氧性脑病(HIE)的临床疗效。方法:将收治的50例HIE患儿,随机分为治疗组26例,对照组24例。治疗组在对照组吸氧、保温、控制惊厥、降颅压、防治感染和支持疗法等的基础上,给予神经节苷脂和高压氧联合治疗措施。结果:治疗组显效19例,有效6例,总有效率为96.15%,对照组显效11例,有效10例,总有效率为87.5%,两组总有效率比较差异有统计学意义(X2=4.36,P<0.05)。结论:神经节苷脂联合高压氧治疗新生儿缺氧缺血性脑病疗效显著,不良反应少,安全有效。
Objective:To explore clinical curative effect of ganglioside(GA) and high pressure oxygen(HPO) on treating Hypoxie-ischemic encephalopathy(HIE).Method:Divided randomly 26 cases of 50 HIE children into treatment group,and 24 into control group.Give the treatment group GA and HPO treatment more while both of the two groups are treated with oxygen,thermal insulation,control of seizures,reducing the intracranial pressure,infection prevention and supportive therapy.Result:19 cases in the treatment group have reaction,and 6 cases effective,with 6.15% total effective rate.While 11 cases in the control group have reaction,and 6 cases effective,with 87.5% total effective rate Statistically significant of the total effective rate Difference between the two group(X2=4.36,P<0.05).Conclusions:The clinical curative effect of GA and HPO on treating HIE is distinct.They have fewer side effects and are safe and sure.So they are worthy of clinical use.
关键词
新生儿缺氧缺血性病
神经节苷脂
高压氧
疗效
Hypoxie-ischemic encephalopathy(HIE)
Ganglioside(GA)
High pressure oxygen(HPO)
Curative effect
