摘要
目的 探讨血管内皮细胞 (vascularendothelialcells ,VEC)损伤及损坏后的功能变化在糖尿病视网膜病变 (diabeticretinopathy ,DR)发病机制中的作用。 方法 检测 5 5例糖尿病 (diabetesmellitus ,DM)患者(包括无视网膜病变组 2 0例 ,背景型视网膜病变组 2 0例 ,增生型视网膜病变组 15例 )及正常人外周血循环内皮细胞 (circulatingendothelialcells ,CEC)数及血浆内皮素 (endothelin ,ET)水平变化 ,并进行比较。 结果 DM患者CEC数及ET水平显著高于正常人 (P <0 .0 0 1) ,两指标呈显著正相关 (r =0 .738,P <0 .0 0 1,n =5 5 )。CEC数及ET水平随DR程度加重而增高。 结论 VEC损伤及由此所致的血浆ET水平增高 ,可能共同参与了DR的病理过程。
Objective To investigate the effect of the damage and functional change of vascular endothelial cells (VEC) on diabetic retinopathy(DR). Methods Circulating endothelial cell (CEC) number and plasma endothelin(ET) level were measured in 18 normal control subjects and 55 patients with diabetes mellitus (DM) consisting of 20 cases of DM with out retinopathy,20 cases of DM with background diabetic retinopathy and 15 cases of DM with proliferative diabetic retinopathy. Results CEC number and plasma ET level in DM were significantly higher than those in normal subjects(P<0.001)respectively.With the progression of DR,CEC number was significantly elevated and plasma ET level was gradually elevated.There was significant positive correlation between CEC number and plasma ET level (r=0.738,P<0.001,n=55). Conclusion VEC damage and elevated plasma ET level induced by VEC damage may play an important role in the development and progression of DR.
出处
《中华眼底病杂志》
CAS
CSCD
北大核心
2000年第3期166-168,共3页
Chinese Journal of Ocular Fundus Diseases
关键词
糖尿病视网膜病变
血管内皮细胞
内皮素
Diabetic retinopathy
Diabetes mellitus
Endothelium,vascular
Endothelins
