摘要
目的：制备双氯芬酸胆碱。方法：以双氯芬酸和胆碱为原料，合成了双氯芬酸胆碱，对其结构进行了紫 外吸收光谱（ＵＶ）、红外吸收光谱（ＩＲ）、质谱（ＭＳ）、核磁共振氢谱（１ＨＮＭＲ）、核磁共振碳谱（１３ＣＮＭＲ）元素分析。结果： 实验条件缓和，产率高达７５．２％，纯度９９．７％以上，产品分子式为Ｃ１９Ｈ２４Ｏ３Ｎ２ＣＬ２，经ＵＶ、ＩＲ、ＭＳ、１ＨＮＭＲ、１３ＣＮＭＲ及元 素分析确定。结论：产品合成工艺简单，产率高，无污染，适于推广应用。
Aim: To reduce the stimulation of diclofenac sodium, a new diclofenac acid salt was prepared.Methods:The diclofenac acid-choline was manufactured by reacting diclofenac acid with choline at the temperature of ５０℃ for some time. Results:The productivity of the product was more than 75.2% (purity above 99.7% ) .The product,with a molecular formula of C19 H24O3N2Cl2, was identified on the basis of spectral data (UV.IR、1HNMR.13CNMR and MS). Conclusion: Its synthetic line has high yield with less industrial pollution.
出处
《河南医科大学学报》
2000年第5期443-444,共2页
Journal of Henan Medical University
基金
河南省教委科研基金资助项目!99150015
