摘要
目的 :探讨血清及腹水乳酸脱氢酶 (LDH)水平在卵巢癌诊治中的意义。方法 :检测 5 0例卵巢癌及 5 5例其他妇科肿瘤术前血清LDH水平 ,检测 2 0例腹水或盆腔冲洗液LDH水平 ,并随访LDH的变化 ,数据经计算机处理。结果 :卵巢癌患者术前血清LDH明显高于子宫恶性肿瘤和卵巢良性肿瘤 (P <0 0 0 1) ,晚期病人高于早期患者(P <0 0 5 ) ,各病理类型之间无明显差异。卵巢癌患者腹水LDH值远高于血清值 ,与良性肿瘤盆腔冲洗液差异极显著 (P <0 0 0 1)。治疗有效患者血LDH下降明显 (P <0 0 1)。血清LDH对卵巢肿瘤的诊断敏感性、特异性、符合率分别为 76 0 %、78 8%、75 9%。结论 :血清及腹水 (盆腔冲洗液 )LDH水平对卵巢癌的诊治有辅助意义 ,其检测方便低廉 。
PURPOSE:To evaluate serum and peritoneal fluid dehydrogenase in ovarian cancer.METHODS:Serum LDH levels of 50 patients with ovarian cancer and 55 cases with other gynecoligic tumors were measured before treatment while peritoneal fluid LDH levels of 20 cases with ovarian neoplasm were detected. After treatment the LDH levels were re measured. All deta were analysed by SPSS 8.0.RESULTS:Serum and peritoneal fluid LDH levels in patients with ovarian cancer were significantly higher than those in patients with benign ovarian neoplasm and endometrial and cervical carcinoma (P<0 001). No difference was observed among the histological types of ovarian carcer. The serum LDH levels of patientswith early ovarian cancer were lower than those of late cases ( P <0 05). After treatment the serum levels in patients of better outcome were significantly reduced ( P <0 01). The diagnostic sensitivity ,speciticity,diagnostic accuracy of serum LDH were 76%, 78.8%, 75.9% respectively.CONCLUSIONS:Serum and peritoneal fluid LDH may be an efficient biochemical marker with convenience and cost benefits in diagnosis and monitoring of ovarian cancer which can be applied in primary hospital.
出处
《中国癌症杂志》
CAS
CSCD
2000年第3期244-246,共3页
China Oncology
