摘要
目的 :探讨羟基喜树碱 (HCPT)、依托泊苷 (VP16 )、5 氟尿嘧啶 (5 FU)联合方案治疗老年人晚期胃癌的疗效和毒副作用。方法 :比较HCPT +VP16 +CF + 5 FU(ELFH)方案与HCPT + 5 FU +VP16 (EFH)方案。结果 :ELFH组 42例有效率为 5 2 4%。EFH组 40例有效率为 42 5 % ,两组疗效比较差异无显著性。ELFH组毒副反应较EFH组发生率高 ,主要为骨髓抑制、恶心呕吐、口腔粘膜炎、腹泻等。结论
Purpose:To study the effects and side effects of HCPT+VP16+CF+5 FU regimen in the treatment of elderly men with advanced gastric cancer. Methods:HCPT+VP16+CF+5 FU regimen was compared with HCPT+VP16+5 FU regimen.Results:42 cases were treated with HCPT+VP16+5 FU regimen with a response rate of 52.4%. 40 cases were treated with HCTP+VP16+5 FU regimen with a response rate of 42.5%. Between them,there was no significant difference in curative effects. The toxicity in HCPT+VP16+CF+5 FU group was more severe than that in HCPT+VP16+5 FU group. It included myelosuppression,nausea,vomity,mucositis. Conclusions:Therefore HCPT+VP16+5 FU regimen is preferable in the treatment of elderly men with advanced gastric cancer.
出处
《中国癌症杂志》
CAS
CSCD
2000年第3期237-238,共2页
China Oncology
