摘要
目的 评价羟基喜树碱联合顺铂和平阳霉素治疗Ⅳ期食管癌的疗效和毒性。方法 经病理证实的46例Ⅳ期食管癌病人，采用羟基喜树碱＋顺铂＋平阳霉素方案：羟基喜树碱10mg连续7天；顺铂30mg／m^2，第1～3天应用；平阳霉素16mg，第1．8天应用，21天为1周期。结果 完全缓解（CR）2例，部分缓解（PR）20例，稳定（SD）18例，进展（PD）6例，总有效率47．8％。初治25例中，CR＋PR15例，有效率为60．0％。复治21例中CR＋PR6例，有效率达28．6％。两组差异有显著性（P〈0．05）。毒副反应为骨髓抑制和胃肠道反应。结论 羟基喜树碱联合顺铂和平阳霉素对Ⅳ期食管癌疗效较好，毒副反应可以耐受。
Objective： To evaluate the clinical efficacy and side offects of advanced （Ⅳ） esophagus carcinoma. Methods ： 46 cases with advanced （ Ⅳ ） esophagus carcinoma were confirmed by pathology. All patients received the regimen of hydroxy camptothecin plus cisplatin and pingyangmycin, hydroxy camptothecin 10mg on D1-7,cisplatin 30mg/m^2 on D1-3,and pingyangmycin 16mg on D1.8,21days were one cycle. ResuIts. The complete rate （CR）2,Partial remission （PR） 20,stable disease （SD） 18,and the pro-gressive disease （PD） 6,the overall response rates （CR-bPR） were 47.8% ,15cases in the 25untreated patients,the response rates （CR-bPR） were 60. 0% ;6 cases in the other patients,the response rates （CR＋ PR） were 28. 6%. Significant difference was observed between the two groups （P〈0.05）. The main side effects were myelo-suppression and degestive tract reaction. Conclusion ： Hydroxy camptothecin plus cisplatin and pingyangmycin is one of the ideal chemical scheme in the treatment of esophagus carcinoma,being feasible and well-tolerated.
出处
《哈尔滨医药》
2006年第3期13-15,共3页
Harbin Medical Journal
