摘要
目的探讨血清胱抑素C(CysC)、尿素氮(BUN)、尿酸(UA)、肌酐(Cr)、β2-微球蛋白(β2-MG)等测定在早期诊断肾功能异常中的临床意义。方法收集206份临床样本,分别为122例健康体检者(健康组)和84例肾功能异常者(异常组),采用CysC测定试剂盒(免疫比浊法)进行检测,同时测定BUN、UA、Cr、β2-MG水平。结果健康组CysC均小于1.09 mg/L,异常组均大于或等于1.09 mg/L,二者比较,差异有统计学意义(P<0.05)。两组CysC、BUN、UA、Cr、β2-MG比较,差异有统计学意义(P<0.05);CysC检测灵敏度为95.2%,与其他检测指标比较,差异有统计学意义(P<0.05)。结论血清CysC测定有助于对肾功能早期损伤及损害程度的判断,是一种特异性强、稳定性好、灵敏度高的检测方法。
Objective To explore the clinical significance of serum cystatin C（CysC）,BUN,UA,Cr,β2-MG in early diagnosis of abnormal renal function.Methods 206 clinical samples were collected including 122 healthy people（the healthy group） and 84 patients with abnormal renal function（the abnormal group）.CysC determination kit（immunoturbidimetry） was adopted to detect BUN,UA,Cr and β2-MG.Results CysC was less than 1.09 mg/L in the healthy group and not less than 1.09 mg/L in the abnormal group,the difference was statistically significant（P〈0.05）.The differences of BUN,UA,Cr and β2-MG between the two groups had statistical significance（P〈0.05）.The sensitivity of Cys C was 95.2%,the difference was statistically significant compared with the other indexes（P〈0.05）.Conclusion CysC detection can help to diagnose early renal damage and judge its damage degree,which is a test method with strong specificity,good stability and high sensitivity.
出处
《现代医药卫生》
2013年第9期1300-1301,共2页
Journal of Modern Medicine & Health
关键词
抑素类
肌酸酐
尿素氮
尿酸
Β2微球蛋白
肾功能
Chalones
Creatinine
Blood urea nitrogen
Uric acid
Beta 2-microglobulin
Renal function
