摘要
目的：研究玉竹提取物B（ExtractionBofpoly－gonatumodoratum，EB-PAOA）对肿瘤的抑制作用。方法：检测肿瘤细胞株CEM增殖和表面分子表达以及观察对小鼠S－180移植瘤的抑制作用。结果：玉竹提取物B10－3ml－1（V/V，以下同）浓度对CEM的增殖有显著的抑制作用，并促进CEM表面分子HLA-I分子、CD2和CD3的表达，尤其对CD2分子的表达作用更为显著，提高了CEM的分化程度。玉竹提取物B对S－180移植小鼠足垫所形成的移植瘤有明显的抑制作用，对移植瘤生长的抑制百分率（Inhibitorypercentage,IP）达68.5％（P＜0．01）；玉竹提取物B10-4ml－1的浓度对S-180腹腔移植的荷瘤小鼠可延长存活期达（10.7±3。8）d，存活率达20％。结论：玉竹提取物B具有显著的抗肿瘤作用。
Objective: To research the inhibitory action of EB-PAOA on tumor. Methods: To assay for the proliferation of CEM and the expression surface molecule in CEM cells. To observe the inhibitory action of EB-PAOA on the S-180 murine tumors in vivo. Results: In 10-3ml-1 (v/v) concentration, EB-PAOA notably inhibits the proliferation of CEM cells and the promotes HLA-I molecule, CD2 and CD3 expression of CEM. Particularly, EB-PAOA has great influence on CD2 expression of CEM. EB-PAOA has great inhibitory action on S-180 murine tumors in the foot plate. The IP of EB-PAOA on S-180 murine tumors in the foot plate rises to 68.5% (P < 0.01). The survival period of S-180 murine tumors in the abdominal cavity is prolonged by EB-PAOA is 10. 7 ± 3. 8 d. Its survival percentage rises 20%. Conclusion: EBPAOA has great antitumor action.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2000年第7期376-377,共2页
Chinese Journal of Immunology
基金
辽宁省教委资助!93130402
