摘要
目的:观察养阴天香丹对大鼠心肌缺血阴虚证的血管内皮功能影响。方法:采用温、燥、利水中药灌胃制造阴虚证模型,再用异丙肾上腺素皮下注射复制心肌缺血模型,并观察养阴天香丹对血管内皮功能的作用。结果:养阴天香丹能显著升高一氧化氮(NO)、血管内皮生长因子(VEGF)、降低血管内皮素-1(ET-1)、肿瘤坏死因子-α(TNF-α)水平。结论:养阴天香丹明显改善大鼠心肌缺血阴虚证的血管内皮功能作用,是改善心肌缺血的有效药物。
Objective ： To study the influence of Yangyin Tianxiangdan on vascular endothelial function in myocardial ischemia of Yin deficiency syndrome in rats models. Methods ： Models of Yin deficiency syndrome were established by oral traditional Chi- nese medicine with warm and dry natures for diuresis, and then models of myocardial ischemia were established by subcutaneous injecting isoproterenol, and the effect of Yangyiu Tianxiangdan on vascular endothelial function was observed. Results： Yangyin Tianxiangdan significantly increased levels of nitric oxide （NO）, vascular endothelial growthfactor（ VEGF）, reduced levels of en- dothelin - 1 （ ET - 1 ） and tumornecrosis factor - c~ （ TNF - a）. Conclusion ： Yangyin Tianxiangdan can significantly improve vas- cular endothelial function in myocardial ischemia Yin deficiency syndrome rats models. It is an effective drug to improve myocardi- al ischemia.
出处
《辽宁中医杂志》
CAS
2013年第5期1041-1042,共2页
Liaoning Journal of Traditional Chinese Medicine
基金
新疆名医名方与特色方剂学实验室开放基金(XJDX0910-2009-09)
新疆自治区中医药管理局中医民族医药青年科技人才专项课题(2010ZMY04)
关键词
养阴天香丹
心肌缺血阴虚证模型
大鼠
血管内皮功能
Yangyin Tianxiangdan
model of myocardial ischemia of Yin deficiency syndrome
rats
vascular endothelialfunction
