摘要
目的研究鸦胆子油乳注射液长期静脉给药对大鼠产生的毒性反应。方法鸦胆子油乳注射液各组(高、中、低剂量)和对照组(等容积的0.9%氯化钠注射液)连续静脉给药26周,分别于给药13周、26周及停药后6周时取大鼠血液和部分脏器进行血液学、血液生化学和病理组织学检查。结果与对照组比较,在给药26周时高剂量组的大鼠血液平均红细胞容积(MCV)、红细胞体积异质性参数(RDW)和网织红细胞百分含量(NRBC%)等指标明显升高,红细胞计数(RBC)、血小板(PLT)等指标明显降低(P<0.05或P<0.01),对以上红细胞系的影响在停药恢复6周后恢复正常。高剂量组的大鼠肾脏功能出现损伤,停药恢复6周后仍无法恢复。结论鸦胆子油乳注射液长期高剂量静脉给药可导致大鼠出现急性肺水肿和溶血性贫血。
Objective To observe the long-term toxic reaction of intravenous injection of brucea javanica oil emulsion in rats. Methods Daily doses ofbruceajavanica oil emulsion injection （high, middle, and low dose group） and equal volume of 0.9% sodium chloride injection （the control group） were used for 26 weeks in rats, respectively. Examina- tions including haematological indexes, biochemical indexes, and histopathology of the blood and organs were performed 13, 26 weeks after administration, and 6 weeks after withdrawal. Results The levels of WBC, RDW, NRBC% in high dose group were significantly higher than those in the control group, and the levels of RBC, PLT in high dose group were significantly lower than those in the control group 26 weeks after administration （P〈0.05 or P〈0.01）. Those changed index- es of red cells regained normal 6 weeks after withdrawal. The kidney function of rats in high dose group showed damage and can＇t regain normal 6 weeks after withdrawal. Conclusion Repeated high doses administration ofbruceajavanica oil emulsion injection could lead to acute pulmonary edema and hemolytic anemia in rats.
出处
《海南医学》
CAS
2013年第9期1261-1263,共3页
Hainan Medical Journal
关键词
鸦胆子油乳
注射液
大鼠
长期毒性
Brucea javanica oil emulsion
Injection
Rat
Long-term toxicity
