摘要
【目的】探讨老年女性乳腺癌患者的临床及病理特征。【方法】选取本院收治的中老年女性乳腺癌患者94例，根据年龄大小分为老年组（≥65岁）33例，中年组（〈65岁）61例。比较两组的临床资料及随访结果。【结果】两组患者体重指数、手术方式相比较差异无显著性（P〉0．05）。老年组患者与中年组比较肿瘤分期晚、并发症发生率高，化疗比例小、化疗耐受性差及随访率低，且两组相比差异均有显著性（P〈0．05）；老年组患者雌激素受体（ER）、孕激素受体（PR）阳性率比中年组高，人表皮生长因子受体2（HER2）阳性率比中年组低，两组相比差异均有显著性（P〈0．05）；两组5年生存率比较，差异无显著性（P〉0．05）。【结论】老年乳腺癌患者有独特的临床和病理特点，在诊治过程中要注重早期诊治，定时督促患者按计划完成化疗和内分泌治疗，加强术后患者的随访，以提高生活质量，改善生存率。
[Objective]To explore the clinical and pathological features of elderly women with breast canc er. [Methods]A total of 94 elderly women with breast cancer admitted to general surgery department in our hospital from July 2004 to Jan, 2012 were chosen. According to the age, all patients were divided into old age group（age≥65 years old, n = 33） and young group（age%65years, n = 61）. Clinical data and follow-up results were compared between the two groups. [Results]There was no significant difference in body mass index and operation mode between two groups（ P ~0.05）. Compared with young group, patients in old age group had late tumor stage, high incidence of complications, small proportion of chemotherapy, poor tolerance and low follow up rate, and there was significant difference between two groups（ P %0.05）. The positive rate of es- trogen receptor（ER） and progesterone receptor（PR） in old age group was higher than that in young group, but the positive rate of human epidermal growth factor receptor2（HER2） in old age group was lower than that in young group, and there was significant difference（ P %0.05）. There was no significant difference in the 5- year survival rate between two groups（P~＇0.05）. [Conclusion]Compared with young patients, the elderly pa- tients with breast cancer have unique clinical and pathological characteristics. Early diagnosis and treatment in the process of diagnosis and treatment of senile breast cancer should be paid attention. Patients should be time- ly supervised to complete chemotherapy and endocrine therapy according to the plan. The follow up of patients after operation should he strengthened in order to improve the quality of life and increase the survival rate.
出处
《医学临床研究》
CAS
2013年第4期771-773,共3页
Journal of Clinical Research
