摘要
究 HL A分子对人类认识生命现象的本质及临床研究有重要作用 ,因此长期以来 HL A是生命科学研究的重点之一。第 13届国际组织相容性大会 (International Histocompatibility Workshop andConference,IHWC)筹备委员会提出的 HL A发展方向 ,第 12届欧洲组织相容性会议展现的 HL A研究新动向及相关文献 ,反映了近期 HL A研究的一些热点。强调 DNA水平的 HL A分型 ,充分认识 HL A基因水平的多态性 ,有助于进一步认识 HL A的免疫生物学功能 ,有助于用流行病学的方法研究多基因遗传性疾病。另一方面 ,由于 HL A分子广泛地与特异性抗原肽结合启动特异性免疫反应 ,充分认识不同 HL A分子结合的抗原肽谱 。
Over a long period of time, biological questions and clinical problems have been the essential motivating factors that arouse great interest in HLA and promote the enormous efforts to research HLA. The new research trends of HLA initiated by the preceding workshops of the coming 13th International Histocompatibility Workshop and Conference(IHWC), the symposium of the 12th European Histocompatibility Conference as well as the related articles were reviewed.The development and the application of DNA based typing for HLA class Ⅰ genes have been emphasized. These efforts to analyze multiple polymorphic genes are important not only for the furthurance of understanding the immunobiology of HLA, but also for the development of model systems that will be useful in future population based epidemiological studies aimed at polygenic diseases such as cancer. Moreover,HLA molecules are broadly specific peptide receptors governig most specific immune responses in humans. A detailed understanding of their function should be an important step towards the development of a rational strategy for immune manipulations (e.g. vaccines).
出处
《中华医学遗传学杂志》
EI
CAS
CSCD
北大核心
2000年第5期355-358,共4页
Chinese Journal of Medical Genetics
基金
国家自然科学基金重大项目!(39993420)
关键词
人类白细胞抗原
分型标准化
抗原肽谱
human leucocyte antigen
standardized DNA based typing
peptide repertoire
