摘要
目的 评估尼卡地平和乌拉地尔在经蝶垂体腺瘤摘除术中控制性降低血压的效果、安全性及其对血流动力学的影响 .方法 选经蝶垂体腺瘤切除术 5 6例 ,分成尼卡地平组和乌拉地尔组 ,观察两药的有效性、安全性 ,控制性降压的效果以及对血流动力学的影响 .结果 持续泵注尼卡地平 (1.5μg· kg- 1· min- 1 )或乌拉地尔 (5 0 μg· kg- 1· min- 1 )均有效地预防经蝶垂体腺瘤摘除术中高血压的发生 ,可控性好 ,无明显的不良反应 .结论 经蝶垂体腺瘤摘除术中用尼卡地平或乌拉地尔均能快速、有效。
AIM To evaluate the efficacy and safety of nicardipine and urapidil in controlling hypotension and their hemodynamic effects during transsphenoidal pituitectomy. METHODS Fifty six patients with transsphenoidal pituitectomy were studied and randomly divided into two groups.Nicardipine ( n =28) and Urapidil ( n =28) were continuously infused during the transsphenoidal operative procedures. The systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR) and side effects were recorded 1 minutes before and 1, 3, 5, 10, 20, 30 minutes after both drugs were infused. RESULTS Both nicardipine [(1.5±0.6) μg·kg -1 ·min -1 ] and urapidil [(50±18) μg·kg -1 ·min -1 ] effectively decreased arterial pressure, and maintained MAP at about (9.3±0.7) kPa. The onset time was rapid, the effects of controlled hypotension were better and no significant side effects were observed. CONCLUSION The advantages of nicardipine or urapidil for controlling hypotesion duing trassphenoidal pituitectomy are rapid onset time, effectiveness and safety.
出处
《第四军医大学学报》
2000年第9期1118-1120,共3页
Journal of the Fourth Military Medical University
