摘要
背景:排汗可将一些溶解于汗液的代谢产物带出体外,在排泄中起辅助作用。现代医学目前还无法恢复严重创伤或烧伤患者的汗腺,如何解决皮肤汗腺的再生及如何培养具有皮肤附属物的"功能性组织工程皮肤"问题已成为当今医学研究中的热点。目的:探讨机体的新陈代谢、汗液的代谢方式,分析组织工程皮肤功能性附属物汗腺再生研究的现状。方法:收集组织工程皮肤功能性附属物再生,特别是排汗的相关研究,分析机体的新陈代谢与排泄方式,汗液代谢的物质和方式,以及目前组织工程皮肤附属物汗腺再生研究的现状。结果与结论:汗液作为排泄系统中重要的一员在维持机体内部的动态平衡,防止代谢产物对身体的损害方面具有不可忽视的地位。理想的功能性组织工程皮肤应具有分泌汗液、排泄废物、调节体温和维持皮肤动态平衡的作用,在大面积烧伤后皮肤创伤修复和重建过程中起着至关重要的作用。已有研究将干细胞与汗腺细胞进行共培养,然后移植到瘢痕创面上进行重建汗腺组织,取得了一定的成功。
BACKGROUND： Perspiration can remove some metabolites dissolved in the sweat out of the body, playing a supporting role in the excretion. Modem medicine cannot restore the sweat glands of severe trauma or bum patients, and how to solve the regeneration of the skin and sweat glands and culture tissue-engineered skin functional appendage has become a hot spot in today＇s medical research. OBJECTIVE： To explore the body＇s metabolism and metabolic way of the sweat, thereby analyzing the functional sweat gland regeneration of tissue-engineered skin. METHODS： Studies addressing the tissue-engineered skin functional appendage regeneration effects on perspiration and metabolism were collected to analyze the body＇s metabolism and excretion ways, sweat metabolites and metabolism methods, as well as the regeneration of tissue-engineered skin appendages. RESULTS AND CONCLUSION： Sweat as an important member in the excretory system cannot be ignored in maintaining the dynamic equilibrium of the body and preventing the body against metabolite damages. Ideal tissue-engineered skin functional appendages have abilities of sweat secretion, excretion of waste, regulating body temperature and maintaining the dynamic equilibrium of the skin, thereby playing a vital role in skin wound repair and reconstruction after extensive burns. Studies have shown that stem cells and sweat gland cells were co-cultured, and then transplanted into the scar wound for sweat gland reconstruction, which has achieved some success.
出处
《中国组织工程研究》
CAS
CSCD
2013年第11期2075-2082,共8页
Chinese Journal of Tissue Engineering Research
基金
国家重点基础研究发展规划资助项目(2012CB518105)
国家自然科学基金面上项目(81171812
81272105)~~
关键词
组织构建
组织构建学术探讨
新陈代谢
排泄
汗液
维生素
蛋白质
激素
毒素
汗腺
皮肤附
属器
国家自然科学基金
tissue construction
tissue construction academic discussion
metabolism
excretion
sweat
vitamins
proteins
hormone
toxins
sweat glands
skin appendages
the National Natural Science Foundation of China
