摘要
以水杨醛、1,2-二溴乙烷、邻苯二胺、对苯二胺、4,4'-二氨基二苯甲烷、4,4'-二氨基二苯醚、联苯胺为原料,经取代、缩合成环,得到一系列新型的席夫碱大环化合物,并对席夫碱大环进行还原,得到结构更稳定,柔韧性更好的仲胺大环。并通过IR、1HNMR和ESI/MS对其结构进行了表征。离子识别研究表明:大环化合物对Na+、Mg2+、Li+无明显作用,对Fe3+和Cu2+有作用。初步生物活性测试表明:席夫碱大环在一定浓度下具有抑菌活性。
Several novel Schiff base macrocyclic compounds were synthesized from 1, 2-dibromoethane, diethylamine, salicylaldehyde, o-phenylenediamine, p-phenylenediamine, 4,4＇- diamino-ether, 4, 4＇-diamino-diphenyl methane, and benzidine by substitution and cyclization. In order to obtain more stable, flexibility structures, the Schiff base macrocyclic compounds were reduced to corresponding secondary amine ones. Their structures were confirmed by IR, t HNMR and EIS/MS. Ion identification research shows that： macrocyclic compounds have no obvious function for Na＋, Mg2. and Li ~ ,but have strong effect for Fe3 ＋ and Cu2＋. Preliminary biological activity test indicated that Schiff base macrocyclic compounds have antibacterial activity in a certain concentra- tion.
出处
《化学试剂》
CAS
CSCD
北大核心
2013年第5期396-398,404,共4页
Chemical Reagents
关键词
大环化合物
席夫碱
阳离子识别
抑菌
macrocyclic compounds
Schiff base
cation rec-ognition
bacteriostat
