摘要
目的探讨乙肝病毒脱氧核糖核酸(HBV-DNA)定量检测和酶联免疫吸附试验(ELISA)检测乙肝血清标志物两种检测方法的相关性及其临床意义。方法对我院860份血清分别采用HBV-DNA定量检测及ELISA法进行检测。结果乙肝病毒血清两对半检测组合(HBVm)模式中大三阳最多,有317例(36.9%),其中HBV-DNA定量检测阳性者294例(92.7%)。其他各种HBVm模式中小三阳和乙型肝炎表面抗原/乙型肝炎表面抗体(HBsAg/HBcAb)阳性所占比例也较高,但是HBV-DNA定量检测阳性率均较低,和大三阳模式比较,差异均有统计学意义(P<0.01)。结论 HBV-DNA检测能够直接反映HBV的存在、复制状态以及传染性的大小,是判断患者病情变化的有效手段。
Objective To explore the relationship arid clinical significance between HBV-DNA quantitative detection and ELISA detection of HBV serum markers. Methods 860 samples of serum in the hospital were tested with HBV-DNA and ELISA methods. Results Among the two pairs of semi detection of hepatitis B serum combination mode （HBVm）, the constituent ratio of HbsAg/HbeAg/HbcAb was highest with 317 cases （36.9%）,and the quantitative detection of HBV-DNA possitive were 294 cases with the positive rate of 92.7%. The positive rate of HBV-DNA quantitative detection in other HBVm mode was lower, and compared with I-IbsAg/HbeAg/HbcAh group, the differences were statistically significant （P〈0.01）.Conclusion HBV-DNA detection could directly reflect the presence of HBV replication status and contagious size, which was an effective means to determine patient＇s condition.
出处
《基层医学论坛》
2013年第10期1228-1229,共2页
The Medical Forum
关键词
乙型肝炎病毒
血清标志物
HBV-DNA定量检测
两对半检测组合模式
HBV Serum markers Quantitative detection of HBV-DNA Two pairs of semi detection of hepatitis B serum combination mode （HBVm）
