摘要
以邻乙氧基苯酚为原料,采用相转移催化法制备化合物3;同时以化合物1为起始原料,经盐酸水解制备化合物2,然后与化合物3发生偶联反应制备得到化合物4,最后在盐酸作用下成盐得到标题化合物。系统研究并确定了最优的工艺条件,现行工艺稳定性好,收率高,产品质量符合欧洲药典标准。目标化合物经质谱,红外及核磁确证。
Compound 3 was prepared by O-ethoxyphenol with the method of phase transfer catalysis. Meanwhile, Compound 1, the starting material, was hydrolyzed in the presence of hydrochloric acid to form Compound 2,which was then reacted with compound 3 by coupling reaction to form compound 4,which was finally reacted with hydrochloric acid to achieve the target material. The optimized process conditions were established hy detailed studies,and the current process shows advantages of well stability, high yield and good product .quality which conforms the requirements of European Pharmacopoeia. The target molecule was characterized by MS,IR and NMR.
出处
《光谱实验室》
CAS
2013年第3期1458-1463,共6页
Chinese Journal of Spectroscopy Laboratory
基金
西北师范大学"青年教师提升计划"资助项目(NWNU-LKQN-10-32)
关键词
盐酸坦洛新
合成
相转移催化
Tamsulosin Hydrochloride Synthesis Phase Transfer Catalysis
