摘要
为探讨丙型肝炎血清中ＩＬ－１α、ＩＬ－６、ＴＮＦ－α、ＩＦＮ－γ的含量及与临床关系，应用ＥＬＩＳＡ法对33例各型丙肝患者检测血清中ＩＬ－１α、ＩＬ－６、ＴＮＦ－α并与健康人群对照，结果发现：丙型肝炎临床各型患者血清中ＩＬ－１α、ＩＬ－６、ＴＮＦ－α含量显著高于对照组（Ｐ＜０．０1）；ＩＬ－１α、ＩＬ－６、ＴＮＦ－α与患者病情轻重呈正相关（Ｐ＜０．０５），慢性丙肝ＩＬ－6含量高（Ｐ＜０．０1）；ＩＦＮ－γ活性低（Ｐ＜０．０５），ＩＬ－１α与IL－６呈正相关。认为ＩＬ－１α、ＩＬ－６、ＴＮＦ－α、ＩＦＮ－γ对丙肝患者病情观察和疗效判断有一定的指导意义。
In order to study the level and sigificance of serum IL-1α、IL-6、TNF-α、IFN-γ of patients with hepatitis C(HC),33 Serum samples were detected from patients with hepatitis by ELISA It showed that the activity of IL-1α、IL-6、TNF-α were higher than control (P<0.01),The positive relationship were found between serum IL-1α、IL-6、TNF-α level and severe degree of liver injury (P<0.05),The serum IL-6 level with chronic HC was higher than with acute HC(P<0.01),while IFN-γ activity lower(P<0.05).It can be helpful to diagnosis of liver injury and determin trentment effect by detection serum of IL-1α、IL-6、TNF-α、IFN-γ.
出处
《临床肝胆病杂志》
CAS
北大核心
2000年第3期161-163,共3页
Journal of Clinical Hepatology
