摘要
探讨内皮素(ET)在慢性肝病患者中的变化规律。采用非平衡竞争性放射免疫法测定血浆中ET水平。128例慢性肝病患者中的ET水平分别为：慢性轻度肝炎（５０．４６±３２．７４）ｐｇ／ｍｌ；慢性中度肝炎（５１．１６±３０．６９）ｐｇ／ｍｌ；慢性重度肝炎（６３．６１±２４．８６）ｐｇ／ｍｌ；肝硬化代偿期（４３．７８±１８．９７）ｐｇ／ｍｌ；肝硬化失代偿期（７９．２９±１４．０２）ｐｇ／ｍｌ；肝癌（７７．００±５９．２０）ｐｇ／ｍｌ。各型慢性肝病的ET水平与正常(３２．３３±３．７０）ｐｇ／ｍｌ比较有显著性升高（Ｐ＜０．０１）。各型之间有显著性差异（Ｐ＜０．０１）。结论 ET随着肝脏损害程度加重而升高，与肝病的慢性化程度相关，ET越高，预后越差。
In order to study the change of the endothelin(ET)level in different type of liver diseases.Use the method of non-equation competition radiommunoassay to detect the plasma ET level 128 patients’ plasma ET level had been detected The mild-chronic hepatitis were 50.46±32.74pg/ml; middle chronic hepatitis were 51.16±30.69pg/ml; severe degree chronic hepatitis were 63.61±24.86pg/ml;compensation phase of liver cirrhosis were 43.78±18.97pg/ml;decompensation phase of liver cirrhosis were 79.29±14.02pg/ml;liver cancer were 77.9±59.20pg/ml.The ET of all above chronic liver diseases were obviously higher than that of control group(P<0.01).Within the different types of chronic liver diseases,there were difference(P<0.01) The worse the prognosis of the liver disease the higher ET livel It maybe has a correlation between ET and the chronic degree of liver diseases It is useful to detecting ET for helping the diagnosis and determining prognosis
出处
《临床肝胆病杂志》
CAS
北大核心
2000年第3期155-157,共3页
Journal of Clinical Hepatology
关键词
慢性肝病
血浆
内皮素
放射免疫法
endothelin
damage of liver
chronic liver disease
