摘要
目的探讨慢性乙型肝炎和肝炎肝硬化患者血浆内皮素-1(ET-1)水平的变化及其与肝纤维化血清指标和门静脉宽度的关系。方法采用放射免疫法测定急性乙型肝炎、慢性乙型肝炎和肝炎肝硬化患者血浆ET-1、血清透明质酸(HA)、层粘蛋白(LN)、Ⅲ型胶原肽(PⅢP)和Ⅳ型胶原(Ⅳ-C)水平。结果23例急性乙型肝炎肝纤维化血清指标中仅HA水平较正常对照组明显升高;81例慢性乙型肝炎和64例肝炎肝硬化患者,血浆ET-1、血清HA、LN、PⅢP和Ⅳ-C水平均较正常对照组明显升高。在慢性乙型肝炎中血浆ET-1、血清HA、LN、PⅢP和Ⅳ-C水平随着肝脏损害程度(轻、中、重度)的加重而逐步升高。在慢性乙型肝炎和肝炎肝硬化患者中,血浆ET-1水平与血清HA、LN、PⅢP和Ⅳ-C水平明显相关;同时ET-1还与患者门静脉宽度明显相关。结论ET-1、HA、LN、PⅢP和Ⅳ-C与慢性乙型肝炎肝脏损害相关;ET-1与慢性乙型肝炎和肝炎肝硬化患者肝纤维化程度和门静脉高压有一定的关系。
Objective In order to study the change of plasma endothelin-1 （ET-1） and its relationship withthe hepatic fibrosis and the portal hypertension in chronichepatitis B and posthepatitic cirrhosis. Methods The radioimmunoassaywas usedtodetect the levels of plasma ET-1, serum hyaluronic acid （HA）, laminin（LN）, type Ⅲ proeollagen（PⅢ P） and collagen type Ⅳ（Ⅳ-C） in 23 cases with acute hepatitis B , 81 cases with chronichepatitis B and 64 cases with posthepatitic cirrhosis. Results The level of serum HA in patientswith acute hepatitis B was significantlyhigherthan that in the control group. The levels of plasma ET-1, serum HA,LN PⅢ P and Ⅳ-C inpatients withchronic hepatitis B and posthepatitic cirrhosiswere significantlyhigherthan that in the control group. The levelsof ET-1, HA, LN, PⅢ P and Ⅳ- Cincreased as the degree of liver damage progressed inpatients with chronic hepatitis 13. The level of plasma ET-1 was not only related to the levels of serum HA, LN, PIll P and Ⅳ-C, but also to the width of portal vein inpatients withchronic hepatitis B and posthepatitic cirrhosis. Conclusion The levels of ET-1, HA, LN, PⅢ P and Ⅳ-C increasedwith the severity of chronic hepatitis B. ET-1 may be related to the hepatic fibrosis and theportalhypertension in patients with chronic hepatitis B and posthepatitic cirrhosis.
出处
《实用肝脏病杂志》
CAS
2007年第2期89-91,共3页
Journal of Practical Hepatology
