期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

寄生虫microRNA研究进展 被引量：2

Progress of research on microRNAs of parasites
原文传递
导出
摘要 microRNAs(miRNAs)是一类大小约21～25 nt、广泛存在于真核生物中的非编码小分子RNA,由约70～90个碱基大小的、具有发夹结构的单链RNA前体经过Dicer酶加工后生成。它们在真核生物基因调控中起着重要作用,广泛参与细胞增殖、分化、发育、代谢、凋亡等多种生理活动。miRNA也广泛参与寄生虫发育过程的生理代谢过程,而与寄生虫侵袭宿主相关的关键miRNA尚乏见报道。本文就目前常用的miRNA研究分析方法及其在寄生虫学研究中的研究进展作一综述。 microRNAs （miRNAs） are small molecules of noncoding RNA, a class size of about 2125 nt widespread in eu karyotes, resulting from singlestranded RNA precursors with the size of 7090 bases of a hairpin structure generated after dicer enzyme processing. They play an important role in eukaryotic gene regulation, widely involved in cell proliferation, differentia tion, development, metabolism, apoptosis and other physiological activities, miRNA extensively involved in the physiological and metabolic processes of the parasite development process, but the key miRNA relevant to parasite invasion of a host still lacks re ports. This paper summarizes the miRNA analytical methods and the progress on its researches in parasitology.
作者 周庆新 周永华 张英 赵中兴 范红结 姚火春
机构地区 南京农业大学动物医学院 江苏省无锡市农业委员会 江苏省寄生虫病防治研究所
出处 《中国血吸虫病防治杂志》 CAS CSCD 2013年第2期197-201,共5页 Chinese Journal of Schistosomiasis Control
关键词 寄生虫 MICRORNA 研究方法 应用 Parasites micro RNA （miRNA） Research approach Application
分类号 R53 [医药卫生—内科学]
  • 相关文献

参考文献66

  • 1Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin- 4 encodes small RNAs with antisense complementarity to lin- 4 [J]. Cell, 1993, 75(5) : 843-854.
  • 2Reinhart BJ, Slack FJ, Basson M, et al. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans [J]. Nature, 2000, 403(6772): 901-906.
  • 3Kim J, Krichevsky A, Grad Y, et al. Identification of many microR- NAs that copurify with polyribosomes in mammalian neurons[J]. Proc Natl Acad Sci USA, 2004, 101 ( 1 ) : 360-365.
  • 4Sunkar R, Girke T, Jain PK, et al. Cloning and characterization of microRNAs from rice[J]. Plant Cell, 2005, 175(5) : 1397-1411.
  • 5Lindow M, krogh A. Computational evidence for hundreds of non-con- served plant microRNAs[J]. BMC Genomics, 2005, 6: 119.
  • 6Xie FL, Huang SQ, Guo K, et al. Computational identification of nov- el microRNAs and targets in Brassica napus [J]. FEBS Lett, 2007, 581(7) : 1464-1474.
  • 7Zhou D, Li S, Wen J, et al. Genome-wide computational analyses of microRNAs and their targets from Canis familiaris [J]. Comput Biol Chem, 2008, 32(1): 60-65.
  • 8Johnsron B J, Hobert OA. MicroRNA controlling left/right neuronal asymmetry in C. elegans[J]. Nature, 2003, 426(6968) : 845-849.
  • 9Bartri DP. microRNAs : genomics, biogenesis, mechanism and func- tion[J]. Cell, 2004, 116(2) : 281-297.
  • 10He L, Hannon GJ. MicroRNAs : small RNAs with a big role in gene regulation[J]. Nat Rev Genet, 2004, 5(7): 522-531.

二级参考文献88

  • 1Barrel DP. MicroRNAs: genomics, biogenesis, mechanism, and function[J]. Cell, 2004, 116(2): 281-97.
  • 2Lai E, Tomancak P, Williams R, et al. Computational identification of Drosophila microRNA genes[J]. Genome Biology, 2003, 4(7): R42.
  • 3Aravin A, Lagos-Quintana M, Yalcin A, et al. The small RNA profile during Drosophila rnelanogaster development[J]. Dev Cell, 2003, 5 (2): 337-50.
  • 4Chatterjce R, Chaudhuri K. An approach for the identification of microRNA with an application to Anopheles gambiae [J]. Acta Biochim Pol, 2006, 53: 303-9.
  • 5Winter F, Edaye S, Huttenhofer A, et al. Anopheles gambiae miRNAs as actors of defence reaction against Plasmodium invasion [J]. Nucl Acids Res, 2007, 35: 6953-62.
  • 6Mead EA, Tu Z. Cloning, Characterization, and expression of microRNAs from the Asian malaria mosquito, Anopheles stephensi [J]. BMC Genomics, 2008, 9: 244.
  • 7Lee R, Feinbaum R, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 [J]. Cell, 1993, 75: 843-54.
  • 8Bushati N. MicroRNA functions [J]. Ann Rev Cell Dev Biol, 2007, 23: 175-205.
  • 9Song Li, Mead EA, Liang SH, et al. Direct sequencing and expression analysis of a large number of miRNAs in Aedes aegypti and a multi-species survey of novel mosquito miRNAs [J]. BMC Genomics, 2009, 10: 581.
  • 10Reinhart BJ, Slack FJ, Basson M, et al. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans [J]. Nature, 2000, 403: 901-6.

共引文献11

同被引文献44

  • 1赵江平,刘金明,程国锋.miRNAs在日本血吸虫不同发育时期的表达情况研究[J].中国动物传染病学报,2013,21(4):29-32. 被引量：5
  • 2Maiden MC, van Rensburg MJ, Bray JE, et al. MLST revisited: the gene-by-gene approach to bacterial genomics[J]. Nat Rev Mi- crobiol, 2013, 11(10): 728-36.
  • 3Heydari H, Wee WY, Lokanathan N, et al. MabsBase.,a Myco- bacterium abscessus genome and annotation database[J]. PLoS One, 2013, 8(4): e62443.
  • 4Pratt-Szeliga PC, Skewes AD, Yan J, et al. Xanthusbase after five years expands to become Openmods[J]. Nucleic Acids Res, 2012, 40(Database issue): D1288-D1294.
  • 5Heydari H, Wee WY, Lokanathan N, et al. MabsBase: a Myco- bacterium abscessus genome and annotation database [J]. PLoS One, 2013, 8(4): e62443.
  • 6Li J, Dai X, Liu T, et al. LegumelP: an integrative database for comparative genomics and transcriptomics of model legumes[J]. Nucleic Acids Res, 2012, 40(Database issue) : D1221-D1229.
  • 7Jewison T, Knox C, Neveu V, et al. lome database[J]. Nucleic Acids Res, DS15-D820.
  • 8YMDB: the yeast metabo- 2012, 40(Database issue) Ahmed J, Worth CL, Thaben P, et al. FragmentStore-a compre hensive database of fragments linking metabolites, toxic molecules anddrugs[J]. Nucleic Acids Res, 2011, 39 (Database issue).. D1049- D1054.
  • 9Ahmed J, Meinel T, Dunkel M, et al. CancerResource: a com- prehensive database of cancer-relevant proteins and compound in teractions supported by experimental knowledge[J]. Nucleic Acids Res, 2011, 39(Database issue): D960-D967.
  • 10Pickett BE, Greer DS, Zhang Y, et al. Virus pathogen database and analysis resource (ViPR) : a comprehensive bioinformatics da-tabase and analysis resource for the coronavirus research communi- ty[J]. Viruses, 2012, 4(11): 3209-26.

引证文献2

二级引证文献13

中国血吸虫病防治杂志
2013年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部