摘要
非小细胞肺癌(NSCLC)是肺癌的一种,它具有极高的病死率。在NSCLC的发生、发展中丝裂原活化蛋白激酶(MAPK)通路异常激活起重要作用,而B-Raf基因是MAPK通路中MEK/ERK最为关键的激活因子,进而对肿瘤细胞的增殖、分化和凋亡等方面起作用。B-Raf基因表达异常存在于NSCLC中并影响它的发生及预后,针对B-Raf基因的靶向治疗是一个新的研究热点。
Non-small cell lung cancer（NSCLC） is one kind ot lung cancer,wtth.hlgtl cleatn rate. enor- mal activation of mitogen-activated protein kinase（MAPK） pathway plays a crucial, role in the pathogenesis of NSCLC,of which B-Raf genes is the most critical activating factor of MAPK pathway MEK/EPK, playing roles in tumor cell proliferation, differentiation, apoptosis, and so on. Abnormal B-Raf expression have been found in NSCLC which affects its development and prognosis. Targeted therapy for B-Raf gene is a new research focus.
出处
《医学综述》
2013年第8期1409-1411,共3页
Medical Recapitulate
