摘要
目的:通过检测信号转导与激活因子3(stat-3)与生存素(survivin)在乳腺癌组织中的表达,探讨它们在乳腺癌发生及发展中的意义。方法:应用免疫组织化学法,检测51例乳腺癌和25例癌旁乳腺组织中stat-3和survivin表达。结果:stat-3在乳腺癌中的表达阳性率高于癌旁乳腺组织(P<0.001);stat-3表达在淋巴结转移组中高于无淋巴结转移组(P<0.05)。stat-3表达与患者年龄、肿瘤大小、组织学分级、临床分期、雌孕激素受体和c-erbB-2均无明显关系(P>0.05)。survivin在乳腺癌中的表达高于癌旁乳腺组织(P<0.001);survivin表达与患者年龄、肿瘤大小、组织学分级、临床分期、淋巴结转移、雌孕激素受体和c-erbB-2均无明显关系(P>0.05)。survivin表达阳性者35例中stat-3表达阳性34例,两者表达呈正相关关系(P<0.05)。结论:stat-3、survivin可能相互协同通过抑制细胞凋亡,在乳腺癌发生、发展中起重要作用。
Objective ：To investigate the significance of the expression of stat-3 and survivin in the genesis and development of breast carcinoma. Methods： Immunohistochemistry S-P was utilized to measure the expression of stat-3 and survivin protein in 51 breast carcinoma tissues and 25 adjacent noncarcerous tissues. Results：The expression of stat-3 protein was higher in breast carcinoma tissues than that in the adjacent noncarcerous tissues （P 〈 0. 001 ） ;the expression of stat-3 protein was higher in the positive lymph node group than in the negative lymph node group （P 〈 0.05 ）. It was not related to the patients＇ age, size of tumor, pathological grades, clinical stages, ER, PR or cerbB-2 （ P 〉 0.05 ）. The expression of survivin protein was higer in breast carcinoma tissues than in the adjacent noncarcerous tissues, and the difference was significant （P 〈 0. 001 ）. The expression of survivin protein had no significant coorelation with the patients＇age, size of tumor, pathological grades, clinical stages, lymph node metastasis, ER, PR or cerbB-2 （ P 〉 0. 05 ）. Of the 35 cases with positive survivin protein expression, positive stat-3 protein was detected in 34 of them. The expression of survivin and stat- 3 had positive correlation in breast carcinoma （ P 〈 0. 05 ）. Conclusions： stat-3 and survivin may play an important role in the carcinogensis and progression of breast carcinoma by inhibiting apoptosis.
出处
《蚌埠医学院学报》
CAS
2009年第7期584-587,共4页
Journal of Bengbu Medical College
