摘要
本文通过10例泌乳素(PRL)瘤和7例生长激素(GH)瘤,手术摘除前后下丘脑-垂体-甲块腺轴功能的观察,发现不论PRL瘤和GH瘤手术后血清三碘甲状腺原氨酸(T_3)较术前均呈非常显著的降低,前者术前后血清总T_3为93.37±17.45ng/dl和71.57±18.84ng/dl,P<0.01;后者术前后T_3为97.85±27.30ng/dl和71.46±23.99ng/dl,P<0.05。而基值促甲状腺激素(TSH)、总甲状腺素(T_4及游离甲状腺素(FT_4)手术前后两组均无显著变化。促甲状腺素释放激素(TRH)兴奋试验、10例PRL瘤和7例GH瘤中分别有7例和5例呈低弱或无反应,提示手术摘除垂体腺瘤可引起垂体TSH储备及T_3水平的下降。
The hypothalamic-pituitary-thyroidal axis function was studied in ten patients with pituibary prolactinomas and seven with growth hormone tumours pre-and post-operatively.There were significant decreases in serum TT3 in both groups ten days after operation compared with that before treatment (PRL tumour: 93.37±17.45v. s. 71.57± 18.84ng/al, P<0.01; and GH tumour: 97.85±27.30 v.s.71,46±23.99ng/dl, P<0.05). No marked changes were found in basal TSH, TT4 or FT4. TSH responses bo TRH were decreased in 7/10 patients with prolactinoma and 5/7 with GH tumour postopefatively. In both PRL and GH tumour patients, serum r-T3 was higher in some and lower in others after operation. The results suggest transient decreases in TSH reserve and serum TT3 levels may result from both physiological stress and destruction of thyrotr6phs after surgical treatment of pituitary adenoma by the operation.
出处
《上海医科大学学报》
CSCD
1990年第3期183-186,共4页
Journal of Fudan University(Medical Science)
关键词
垂体肿瘤
腺瘤
下丘脑
甲状腺轴
hypothalamie-pituitary-thyroidal axis
prolactinoma
growth hormone tumour
thyrotrophin-releasing hormone stimulation test
